Insulin Sensitivity Clinical Trial
Official title:
Effect of Consumption of Non Caloric Sweeteners and Insulin Sensibility
This study will compare the effect of acute consumption of two carbonated drinks, sweetened with sugar or with non-caloric sweeteners, over the insulin response of healthy adults who normally consumed foods or drinks that contain non-caloric sweeteners
During the last decades there has been a sustained increase in prevalence of overweight and
obesity and, along with it, of chronic noncommunicable diseases. There have been addressed
various management strategies, including sugar replacement for Non-caloric Artificial
Sweeteners (NAS). Nevertheless, in several cohort studies it has found the opposite effect,
it has observed associations between the consumption of NAS with greater weight gain and
increased risk of type 2 diabetes and metabolic syndrome. In clinical trials, in both humans
and mice, there has been greater association with glucose intolerance, being 3 possible
mechanisms: 1) dysbiosis of the intestinal microbiota; 2) altered regulation of appetite
cephalic phase and secretion of glucagon like peptide-1 (GLP-1); and 3) increased intestinal
glucose absorption via increased Sodium-Glucose Linked Transporter-1 (SGLT-1) and Glucose
transporter 2 (GLUT2), transporters to glucose absorption.
In the following review the major findings in the literature regarding the consumption of NAS
and its deleterious effects on human health will be studied.
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