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Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim2) — MicroB2  

Insulin Sensitivity Clinical Trial

Official title:
Mechanism of Microbiome-induced Insulin Resistance in Humans (Aim2)

Clinical Trial Summary

The purpose of this study is to determine whether microbiome modulation and an experimental reduction in plasma LPS concentration improve inflammation and insulin action in insulin resistant (obese and T2DM) subjects.

Clinical Trial Description

In this Aim we will test the hypothesis that lowering lipopolysaccharide (LPS) concentration in the circulation will improve systemic (muscle) inflammation and glucose metabolism in insulin resistant (obese and T2DM) subjects by protecting the intestinal barrier with a synbiotic (Bifidobacterium longum R0175 and oligofructose) or by sequestering LPS in the gastrointestinal lumen with sevelamer. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02127125
Study type Interventional
Source The University of Texas Health Science Center at San Antonio
Contact
Status Completed
Phase Phase 2
Start date April 10, 2014
Completion date September 10, 2018
View Details
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