Effect of Low-carbohydrate/High-fat Diet on Glucose Tolerance and Lipid Profile in Lean, Healthy Women

Insulin Sensitivity Clinical Trial

— LCHF  

Official title:

Effect of Low-carbohydrate/High-fat Diet on Glucose Tolerance and Lipid Profile in Lean, Healthy Women

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02005224
• Other study ID #: AMUC-NIH-LCHF-P1-2012
• Status: Completed
• Phase: N/A
• First received: December 4, 2013
• Last updated: December 6, 2013
• Start date: August 2012
• Est. completion date: March 2013

Study information

• Verified date: December 2013
• Source: Atlantis Medical University College
• Contact: n/a
• Is FDA regulated: No
• Health authority: Norway:National Committee for Medical and Health Research EthicsNorway: Regional Ethics Commitee
• Study type: Interventional

Clinical Trial Summary

Intervention studying the effect of a low-carbohydrate/high-fat (LCHF) diet as well as on bout of exercise in combination with either a normal diet or a LCHF diet, in relation to glucose metabolism, insulin sensitivity, lipid profile and body composition.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 17
• Est. completion date: March 2013
• Est. primary completion date: November 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Females

• Normal weight

• BMI between 18.5 and 25

• Moderately trained

Exclusion Criteria:

• Smokers/tobacco users

• pregnancy

• familial cardio-vascular-disease

• diabetes or reduced glucose tolerance

• under- or overweight (BMI under 18.5 or over 25)

• top athletes

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Insulin Resistance
• Insulin Sensitivity
• Weight

Intervention

Other:
• LCHF diet and a bout of exercise
Low-carbohydrate/high-fat diet; effect on insulin sensitivity, lipid profile, weight and body composition. Participants ingested LCHF diet for three weeks before undergoing an oral glucose tolerance test. The same afternoon the participated in an one hour indoor bicycle training at 75% at HFpeak. The following morning they underwent a new oral glucose tolerance test. Body composition and weight were measured before and after the intervention. Oral glucose tolerance test was also performed before the intervention for baseline. Blood samples were collected before and after the intervention for lipid profile analyses.

Locations

Country	Name	City	State
Norway	Norwegian School of Sport Sciences	Oslo

Sponsors (2)

Lead Sponsor	Collaborator
Atlantis Medical University College	Norwegian School of Sport Sciences

Country where clinical trial is conducted

Norway, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Area under the curve glucose (0, 15, 30, 45, 60, 90 and 120 min)	performed by oral glucose tolerance test, 75 g glucose, 300 ml water	-1 week, 3 weeks	No