Insulin Sensitivity Clinical Trial
— VIVIDOfficial title:
Vitamin D, Vascular Function, and Insulin Sensitivity in Adults [The VIVID Study
The overall objectives of this study are to examine the relationships between circulating
vitamin D, insulin sensitivity, and multiple indices of vascular function and to examine
whether vitamin D deficiency in African Americans (AA) and White Hispanics (WH) is
responsible for ethnic differences in insulin sensitivity and hypertension in AA, WH and
European Americans (EA), as well as mechanisms underlying the association between insulin
resistance and blood pressure. We hypothesize that 1) serum 25(OH)D is associated with
insulin sensitivity and vascular functioning, independent of adiposity, 2) lower insulin
sensitivity and vascular functioning in AA and WH relative to EA is due to lower circulating
25(OH)D in AA, and 3) the relationship between insulin resistance and vascular dysfunction
is mediated by 25(OH)D.
Acronyms: African American (AA), European American (EA), White Hispanics (WH), Serum
25-hydroxy vitamin D (25()H)D, Body mass index (BMI), Alabama (AL).
Status | Completed |
Enrollment | 63 |
Est. completion date | December 2013 |
Est. primary completion date | December 2012 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 19 Years to 60 Years |
Eligibility |
Inclusion Criteria: - African American (AA), White Hispanic (WH), and European American (EA) race - Ages 19-60 years - Negative urine pregnancy test - No evidence of diabetes - Not on medications that can affect vascular functioning or insulin sensitivity Exclusion Criteria: - BMI > 32 kg/m2 - Diabetes or any chronic diseases - Use of medication(s) known to influence body composition, vascular function, or glucose metabolism - Regular smoking - Regular use of illegal drugs and pregnancy |
Observational Model: Cohort, Time Perspective: Cross-Sectional
Country | Name | City | State |
---|---|---|---|
United States | University of Alabama | Birmingham | Alabama |
Lead Sponsor | Collaborator |
---|---|
University of Alabama at Birmingham |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Insulin sensitivity | Cross sectional study: at first study visit | No | |
Secondary | Vascular function | Cross sectional study: at second study visit, within 2 weeks of first study visit | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
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