Clinical Trial Details
— Status: Terminated
Administrative data
NCT number |
NCT05518942 |
Other study ID # |
202200998B0A3 |
Secondary ID |
|
Status |
Terminated |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
October 26, 2022 |
Est. completion date |
April 19, 2023 |
Study information
Verified date |
April 2024 |
Source |
Taipei Medical University |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
Insomnia is the most common sleep disorder in patients with primary brain tumors. In the
past, 21.5% to 59.2% of patients with primary brain tumors suffer from insomnia symptoms. In
addition to hypnotics, nonpharmacological interventions for insomnia in patients with brain
tumors are still lacking. When using hypnotics may cause daytime sleepiness, cognitive
impairment, and increase the risk of cancer, seeking an effective intervention is of clinical
importance. Sensorimotor rhythm neurofeedback therapy has been shown to improve insomnia in
different populations. However, its effect on insomnia has not been explored in patients with
brain tumors. We, therefore, aim to investigate the feasibility and effect of sensorimotor
rhythm neurofeedback in improving insomnia in patients with benign brain tumors after surgery
and to examine the correlation between the degree of insomnia improvement and quality of life
changes after receiving sensorimotor rhythm neurofeedback.
Description:
Brain tumors are mainly divided into primary and metastatic, and are further divided into
benign and malignant according to the pathological type. Among them, meningioma and pituitary
tumor are the top two most common primary benign brain tumors, accounting for 36.1%
respectively. -54.5% and 10-15%, while the most malignant glioblastoma accounts for 45-49.1%
of primary malignant brain tumors. Among them, glioblastomas are more common in men and
meningiomas are more common in women.
Insomnia is the most common sleep disorder in patients with primary brain tumors. Insomnia
refers to difficulty falling asleep, staying awake and unable to fall asleep while sleeping,
frequently waking up during sleep period or shortening sleep time, resulting in still feeling
tired after getting up and affecting daily life functions. In the past, in terms of the
prevalence of insomnia, primary brain 21.5%~59.2% of patients with tumor had insomnia
symptoms, and if subdivided into benign, 46.8% of patients with primary benign brain tumor.
According to the results of the study, patients with primary brain tumors still have
widespread and persistent insomnia problems after treatment, and even up to one year after
surgery, there are still studies showing insomnia problems. Savard et al (2011) reported that
insomnia is also a cancer A common and persistent problem among patients, the attack rate of
insomnia generally decreased over time, but remained prevalent (36%) even at the end of 18
months. However, in real life, although insomnia has a high attack rate and a high burden on
the family, and even affects the overall quality of life of patients, it is often not valued
and treated.
Neurofeedback (NFB), also known as brain wave training, is a method to help subjects
consciously control their brain waves. In order to reflect the state of brain activity, the
software analyzes the measured brain waves and provides feedback signals to teach individuals
to self-regulate brain waves. After repeated training, the target brain waves can be
generated. When the threshold is reached, it will give visual and auditory feedback.
Neurofeedback has been used clinically in many diseases and healthy individuals that cannot
be effectively treated with drugs, such as insomnia, ADHD, epilepsy, fibromyalgia,
depression, anxiety, pain, learning and memory, etc. For insomnia, the use of neurofeedback
therapy can help people who usually take an hour or so to fall asleep fall asleep faster.
According to Lambert-Beaudet et al. (2021) reviewing the latest research on the use of
neurofeedback in the treatment of insomnia, the enhancement of sensorimotor rhythm
neurofeedback to improve insomnia was the most included and confirmed to improve insomnia.
And multiple studies have confirmed that sensorimotor rhythm neurofeedback enhancement
training can lead to increased sleep spindle density, decreased sleep onset latency,
increased total sleep time, and decreased wake-up after falling asleep. Therefore,
sensorimotor rhythm neurofeedback enhancement training can be an effective method for
non-drug intervention in the treatment of insomnia. Given that the effects of sensorimotor
rhythm neurofeedback training on insomnia have not been studied in patients with benign brain
tumors after surgery, further studies in this group are warranted.