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Cannabinol Use in Patients With Insomnia Disorder — CUPID  

Insomnia Disorder Clinical Trial

Official title:
A Randomised, Double-blind, Placebo-controlled, Single-dose, Crossover, Pilot Study Investigating the Effects of Cannabinol (CBN) 30 mg and 300 mg on Sleep Architecture and Next-day Function in Insomnia Disorder

Clinical Trial Summary

This study aims to investigate the acute effects of cannabinol (CBN) 30 mg and 300 mg, versus placebo, on sleep architecture and next-day functioning in adults aged 25-65 years with chronic insomnia disorder.

Clinical Trial Description

This is a randomised, double-blind, placebo-controlled, three-arm, crossover, single-centre, proof-of-concept study in twenty participants with chronic insomnia disorder (as per clinician diagnosis and Insomnia Severity Index [ISI] Score ≥15). Across three overnight treatment sessions, participants will receive single dose oral liquid 30 mg cannabinol (CBN), 300 mg CBN, and matched placebo. Participants will undergo overnight sleep assessment using in-laboratory polysomnography (PSG) to examine CBN-related changes to sleep parameters; and various objective and subjective measures of sleep and next-day neurobehavioral function. Each treatment session will be separated by the two-week washout period. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05344170
Study type Interventional
Source Woolcock Institute of Medical Research
Contact
Status Completed
Phase Phase 1/Phase 2
Start date August 24, 2022
Completion date September 5, 2023
View Details
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