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Passive Smoking and LL-37 in Children

Periodontal Health Clinical Trial

Official title:
Salivary LL-37 and Periodontal Health in Children Exposed to Passive Smoking

Clinical Trial Summary

This study investigates the salivary LL-37 in passive smoking-exposed and unexposed children and the association between salivary LL-37 levels and periodontal clinical parameters in these children.Unstimulated salivary samples were collected from 180 children (90 passive smoking-exposed and 90 passive smoking-unexposed)

Clinical Trial Description

Diverse mechanisms conduce to the detrimental periodontal effects of passive smoking, including alteration of both microbial and host response factors.

Antimicrobial peptides are considered to be an important intermediate step in initiating an initial immune response against the microbial side of the oral gingival epithelium and in the transition to acquired immunity.

LL-37 has a wide antimicrobial activity against both cariogenic and periopathogenic bacteria and its role in maintaining oral health has recently been stated ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03639376
Study type Observational
Source Kirikkale University
Contact
Status Completed
Phase
Start date November 2016
Completion date June 2018
View Details
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