Injection Site Irritation Clinical Trial
Official title:
Comparison of Large Antecubital Vein Versus Small Vein on Dorsum of Hand for the Prevention of Propofol Injection Pain
NCT number | NCT04673500 |
Other study ID # | KingKhalidUH |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | May 2013 |
Est. completion date | May 2014 |
Verified date | December 2020 |
Source | King Khalid University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Title: Assessment of pain on lidocaine-Propofol admixture injection: Comparing large antecubital vein and small vein dorsum of hand. - Objective: To evaluate the pain on Propofol - lidocaine admixture injection using different sizes of veins on upper limb. - Design: Prospective randomized clinical trial Place and duration of study: Department of Anesthesia, King Saud University Riyadh May 1, 2013 - May 31, 2014). - Patient and methods: Total 160 adult patients were divided in two groups. Age 20-50 years of either gender, American Society of Anesthesiologist (ASA) class 1 and 2, scheduled for elective surgery under general anesthesia were included in the study. Patients with known history of allergy to lidocaine or Propofol, obese patients, anticipated difficult intubation, already on any analgesics and pregnant patients were excluded from the study. Both groups received an admixture of Propofol (1%) - lidocaine (2%) on induction of anesthesia through antecubital vein (Group- 1) or through a vein on dorsum of hand (Group- 2). Pain was assessed as none, mild, moderate or severe. Results: Moderate to severe pain on intravenous injection of Propofol-lidocaine admixture through antecubital vein and small vein on dorsum of hand was 20% vs 71%. Conclusion: There is marked reduction of pain when Propofol - lidocaine admixture was injected through antecubital vein as compared to small vein on dorsum of hand. - Key words: Propofol, injection, pain
Status | Completed |
Enrollment | 160 |
Est. completion date | May 2014 |
Est. primary completion date | May 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years to 50 Years |
Eligibility | Inclusion Criteria: - Aged 20 to 50 years of either gender - ASA ( American Society of Anesthesia) class 1 and 2 - Scheduled for elective surgical procedure under general anesthesia Exclusion Criteria: - Patients with known history of allergy to lidocaine or Propofol - Obese patients - Anticipated difficult intubation - ASA 3 and 4 - Already on any analgesics and pregnant patients |
Country | Name | City | State |
---|---|---|---|
Saudi Arabia | Abdul Sattar Narejo | Riyadh |
Lead Sponsor | Collaborator |
---|---|
King Khalid University Hospital |
Saudi Arabia,
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* Note: There are 15 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Assessment of severity of pain on propofol injection | A 20 gauge intravenous catheter was inserted either in large antecubital vein or in a small vein on dorsum of hand. An initial 30% of a mixture of propofol lidocaine was given to assess the severity of pain on propofol injection before the patient sleeps. The pain on propofol injection was assessed by numerical rating scale (NRS).
0-10, where 0 is no pain and 10 is worst pain imaginable |
From preoperative to day one postoperative | |
Secondary | Heart rate | Heart rate was assessed in association with pain on propofol injection | From base line pre-propofol injection to Intraoperative after full dose of propofol injection. |
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