Inhibition (Psychology) Clinical Trial
Official title:
Memory and Cognitive Control for Optimal Aging: Study on the Effect of Cognitive Interventions, Cerebral Mechanisms Involved and Processes Promoting Transfer
Verified date | January 2020 |
Source | Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Formal education and cognitively stimulating hobbies and profession have a protective effect against age-related cognitive decline and Alzheimer's disease. It is therefore possible that providing cognitively stimulating interventions at a later age increases neuroplasticity and brain resilience. Processes of updating and inhibition are both impaired by aging. Several studies have shown that updating can be improved but very few studies targeted inhibition in spite of the fact that it is impaired in older adults. The aim of this study is to assess the effect of cognitive interventions that will target either of these two components. The investigators will examine the effect on behavior, brain measures and transfer tasks. The investigators will also assess whether the efficacy varies as a function of personal variables such as prior cognitive profile, reserve proxies, genetic polymorphisms and brain markers.
Status | Completed |
Enrollment | 90 |
Est. completion date | December 20, 2019 |
Est. primary completion date | December 20, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 60 Years to 85 Years |
Eligibility |
Inclusion Criteria: - French-speaking - Right-handed - Sufficient visual and auditory acuity to undergo neuropsychological tests and to do the interventions. - Sufficient delayed recall score above the education-adjusted cut-offs (=9 for 16+ years of education; =5 for 8-15 years of education; =3 for 0-7 years of education) at the Logical Memory test (Wechsler Memory Scale, maximum score 25). Exclusion Criteria: - Answer 'Yes' to the two following questions: "Do you feel like your memory is becoming worse?" "Does this worry you?" (to exclude subjective cognitive decline). - The presence of a disease or injury of the central nervous system: moderate to severe chronic static leukoencephalopathy (including previous traumatic injury), multiple sclerosis, a serious developmental handicap, subdural hematoma (past or current), subarachnoid haemorrhage (past or current), primary cerebral tumour or cerebral metastases, epilepsy (current), dementia or another neurodegenerative disease, and other rarer brain illnesses. - Symptomatic stroke within the previous year. - Alcoholism or substance abuse - History of intracranial surgery. - Major surgery within last 2 months. - General anesthesia in the past 6 months. - Serious comorbid condition that, in the opinion of the study investigator, is likely to result in death within a year. - Major depression or anxiety. - Schizophrenia or other major psychiatric disorder (e.g., bipolar disorder). - Individuals where French is not sufficiently proficient for clinical assessment and neuropsychological testing. - Unable to undergo MRI scan due to medical contraindications or inability to tolerate the procedure. - Plans on moving outside the province within the next 2 months. |
Country | Name | City | State |
---|---|---|---|
Canada | CRIUGM | Montréal | Quebec |
Lead Sponsor | Collaborator |
---|---|
Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal | Natural Sciences and Engineering Research Council, Canada |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Effect of moderators: Polymorphisms. | Presence/absence of polymorphisms : Brain-derived neurotrophic factor (BDNF), Catechol-O-Methyltransferase (COMT) and Apolipoprotein (APOE)-e4 taken from a salivary sample collected using an Oragene OG-500 collection kit. | 3rd week after intervention starts (after the 6th training session) | |
Other | Effect of moderators: Cognitive reserve proxies. | Scores on the reserve-proxy questionnaire (from Rami L, Valls-Pedret C, Bartres-Faz D, et al. 2011). | within the 2 weeks before intervention starts | |
Other | Effect of moderators: Intracranial volume. | Overall intracranial volume taken from MRI scan with a T1-weighted 3D-MPRAGE sequence (TR/TE 2300/2.98ms, Fa 9°, FOV = 256*256, matrix 256*256, voxels 1mm³, 192 slices). | within the 2 weeks before intervention starts | |
Other | Effect of moderators: White Matter Lesions (WML). | The WML will be quantified in mm3 (De Carli et al. 2005) from the FLAIR sequence (TR/TE 9000/120 ms, Fa 90°, FOV 240*240, matrix 256*256, voxels 0.9*0.9*3 mm, 48 slices). | within the 2 weeks before intervention starts | |
Other | Effect of moderators: Regional gray matter volumes in Prefrontal and lateral temporal cortices, Basal ganglia and Hippocampi. | A T1-weighted 3D-MPRAGE sequence (TR/TE 2300/2.98ms, Fa 9°, FOV = 256*256, matrix 256*256, voxels 1mm³, 192 slices) will be used to measure regional gray matter volume. | within the 2 weeks before intervention starts | |
Other | Effect of moderators: Cortical thickness in Prefrontal regions and lateral temporal cortices. | A T1-weighted 3D-MPRAGE sequence (TR/TE 2300/2.98ms, Fa 9°, FOV = 256*256, matrix 256*256, voxels 1mm³, 192 slices) will be used to measure cortical thickness (FreeSurfer 5.3). | within the 2 weeks before intervention starts | |
Other | Effect of moderators: Task related activation in prefrontal and lateral temporal cortices, Basal ganglia and Hippocampi. | Functional activations. Simultaneous multislice (accelerator factor = 6), echo polar (EPI) imaging: TR/TE 785/30 ms, Fa 54°, FOV 192*192, matrix 64*64, voxels 3 mm³, 39 slices) will be measured in association with a N-back task and a counting stroop. | within the 2 weeks before intervention starts | |
Other | Effect of moderators: Sex. | Male vs Female. | within the 2 weeks before intervention starts | |
Primary | Changes on the updating composite measure (Proximal outcome). | An updating composite score will be computed by averaging z-scores from the Keep track task and the Running span task. | within the 2 weeks before intervention starts; 3rd week after intervention starts (after the 6th training session); 6th week (after the 12th training session) | |
Primary | Changes on the inhibition composite measure (Proximal outcome). | An inhibition composite score will be computed by averaging z-scores from the Anti-saccade and the Victoria Stroop Test. | within the 2 weeks before intervention starts; 3rd week after intervention starts (after the 6th training session); 6th week (after the 12th training session) | |
Secondary | Transfer to complex working memory measure: the Alpha-span task (Distal outcome). | Accuracy on the alphabetic portion of the Alpha-span task | within the 2 weeks before intervention starts; 1st week after intervention starts (after the 3rd training session); 3rd week (after the 6th training session); 4th week (after the 9th training session); 6th week (after the 12th training session). | |
Secondary | Transfer to complex working memory measure: the Reading span task (Distal outcome). | Accuracy on the Reading span task. | within the 2 weeks before intervention starts; 1st week after intervention starts (after the 3rd training session); 3rd week (after the 6th training session); 4th week (after the 9th training session); 6th week (after the 12th training session). | |
Secondary | Transfer to complex working memory measure: the virtual car ride task (Distal outcome). | Average z-score computed with the verbal and visual (accuracy and RT) components of the divided attention virtual reality task. | within the 2 weeks before intervention starts; 1st week after intervention starts (after the 3rd training session); 3rd week (after the 6th training session); 4th week (after the 9th training session); 6th week (after the 12th training session). | |
Secondary | Brain structure: Regional gray matter volumes in Prefrontal and lateral temporal cortices, Basal ganglia and Hippocampi. | A T1-weighted 3D-MPRAGE sequence (TR/TE 2300/2.98ms, Fa 9°, FOV = 256*256, matrix 256*256, voxels 1mm³, 192 slices) will be used to measure regional gray matter volume. | within the 2 weeks before intervention starts; 3rd week after intervention starts (after the 6th training session); 6th week (after the 12th training session) | |
Secondary | Brain structure: Cortical thickness in Prefrontal regions and lateral temporal cortices. | A T1-weighted 3D-MPRAGE sequence (TR/TE 2300/2.98ms, Fa 9°, FOV = 256*256, matrix 256*256, voxels 1mm³, 192 slices) will be used to measure cortical thickness (FreeSurfer 5.3). | within the 2 weeks before intervention starts; 3rd week after intervention starts (after the 6th training session); 6th week (after the 12th training session) | |
Secondary | Brain function: Updating related activation. | Functional activations. Simultaneous multislice (accelerator factor = 6), echo polar (EPI) imaging: TR/TE 785/30 ms, Fa 54°, FOV 192*192, matrix 64*64, voxels 3 mm³, 39 slices) will be measured in association with a N-back task. | within the 2 weeks before intervention starts; 3rd week after intervention starts (after the 6th training session); 6th week (after the 12th training session) | |
Secondary | Brain function: Inhibition related activation. | Functional activations. Simultaneous multislice (accelerator factor = 6), echo polar (EPI) imaging: TR/TE 785/30 ms, Fa 54°, FOV 192*192, matrix 64*64, voxels 3 mm³, 39 slices) will be measured in association with a counting stroop. | within the 2 weeks before intervention starts; 3rd week after intervention starts (after the 6th training session); 6th week (after the 12th training session) |
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