Inhalation Anesthesia Clinical Trial
Official title:
Comparison of Intranasal Midazolam or Dexmedetomidine on Epileptiform EEG During Sevoflurane Mask Induction in Children
Induction with high sevoflurane concentrations may trigger epileptiform
electroencephalographic activity without motor or cardiovascular manifestations in healthy
patients. No other symptoms were associated in this series, and only electroencephalographic
monitoring allowed the diagnosis. Midazolam and dexmedetomidine are sedatives commonly used
in children before surgery. Although the mechanisms are different, both have been reported in
antiepileptic effects.
This study was designed to compare the effects between intranasal midazolam or
dexmedetomidine on epileptiform EEG during sevoflurane mask induction in children.
Anaesthesia was induced with 8% sevoflurane. The patients were randomly assigned to Group A
(n=15, preoperative intranasal normal saline), Group B (n=15, preoperative intranasal
0.25mg/kg midazolam), and Group C (n=15, preoperative intranasal 1μg/kg dexmedetomidine). An
electroencephalogram was recorded before and during induction up to 10 min after the start of
induction.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04645316 -
The Effect of Sevoflurane and Desflurane on Clara Cell Protein on the Lung
|
N/A | |
| Recruiting |
NCT04483258 -
Sevoflurane Insufflation vs Intravenous Sedation for Radiotherapy in Pediatric Patients
|
N/A | |
| Completed |
NCT04036487 -
Effects of General Anesthesia on Quality of Recovery After Transaxillary Endoscopic Breast Augmentation
|
N/A | |
| Completed |
NCT06269328 -
Measuring Sleep Quality In Patients That Posterior Spinal Instrumentatıon Plannıng
|
N/A | |
| Recruiting |
NCT04273035 -
Handheld-multimedia Versus Oral Midazolam in Pediatric on Perioperative Anxiety
|
Phase 4 | |
| Recruiting |
NCT05615194 -
The Impact of a Single Dexmedetomidine Bolus on Intraoperative Sevoflurane Consumption (DEXHALE)
|
N/A |