Transversus Abdominis Plane(TAP) Block, Local Infiltration and Intravenous Dexketoprofen in Inguinal Hernia Repair

Inguinal Hernia Clinical Trial

— Analgesia  

Official title:

Comparison of Postoperative Analgesic Efficacy of Preemptive Ultrasound-guided Transversus Abdominis Plane Block, Ultrasound-guided Local Infiltration and Intravenous Dexketoprofen in Inguinal Hernia Repair

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04227912
• Other study ID #: SBUGaziYasargilTRH
• Status: Completed
• Phase: N/A
• Start date: February 11, 2019
• Est. completion date: October 1, 2019

Study information

• Verified date: January 2020
• Source: Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study evaluates the compare the effects of ultrasound guided TAP block, local anesthetic infiltration to the incision line and intravenous dexketoprofen on postoperative analgesic efficacy and rescue tramadol consumption in inguinal hernia repairs.

Description:

Currently, multimodal techniques are used in inguinal hernia repairs in addition to pharmacological and regional techniques for postoperative analgesia.TAP block is performed on the principle of hydrodissection of the fascia between the internal oblique and transversus abdominis muscles of the abdominal wall muscles with local anesthetic drugs. Local anesthetic drugs provide analgesic effect up to 24 hours in the postoperative period by blocking the T6-L1 nerves in the facial plane. Local anesthetic infiltration which is one of the regional anesthetic techniques, is another method of postoperative analgesia. intravenous analgesic drug is also used as pharmacological postoperative analgesia method in most clinics.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 120
• Est. completion date: October 1, 2019
• Est. primary completion date: October 1, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Subject who aged 18-75 years

• American Society of Anesthesiologist (ASA) I-III

• Subject undergoing unilateral or bilateral inguinal hernia repair

Exclusion Criteria:

• Subject under 18 and over 75 years of age

• ASA IV

• History of allergy to agents

• Analgesic drug use in the last 48 hours

• Morbid obese (BMI> 35)

• Confusion

• Coagulopathy

• Local infection at the injection site

• Subject with heart, lung, hematologic, metabolic and endocrine disease

• Subject who did not want to be included in the study

• Subject who refused the spinal anesthesia

• Subject who failed the spinal anesthesia

Related Conditions & MeSH terms

• Hernia
• Hernia, Inguinal
• Inguinal Hernia

Intervention

Other:
• Transversus abdominis plane block
Before surgery, Ultrasound-guided TAP block was performed preemptively to Group TAP patients.
• Local anesthetic infiltration
Before surgery, Ultrasound-guided Local anesthetic infiltration to the surgical incision line was performed preemptively to Group Local patients.
• Intravenous dexketoprofen
Before surgery, 50 mg intravenous dexketoprofen was performed preemptively to Group dexketoprofen patients.

Locations

Country	Name	City	State
Turkey	University of Health Sciences Gazi Yasargil Training and Research Hospital	Di?yarbakir	Eyalet/Yerleske

Sponsors (1)

Lead Sponsor	Collaborator
Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital

Country where clinical trial is conducted

Turkey, 

References & Publications (2)

Joshi GP, Rawal N, Kehlet H; PROSPECT collaboration, Bonnet F, Camu F, Fischer HB, Neugebauer EA, Schug SA, Simanski CJ. Evidence-based management of postoperative pain in adults undergoing open inguinal hernia surgery. Br J Surg. 2012 Feb;99(2):168-85. d — View Citation

Petersen PL, Mathiesen O, Stjernholm P, Kristiansen VB, Torup H, Hansen EG, Mitchell AU, Moeller A, Rosenberg J, Dahl JB. The effect of transversus abdominis plane block or local anaesthetic infiltration in inguinal hernia repair: a randomised clinical tr — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Postoperative rescue tramadol consumption	The mean tramadol consumption in the first 24 post-operative hours	24 hours
Secondary	Analgesic efficacy	Postoperative visual analog scale score recorded 0-10 (0 = no pain, 10 = severe pain) at 30. min, 1, 2, 4, 8, 12, 16 and 24 hours postoperatively	24 hours
Secondary	Postoperative nausea-vomiting	Postoperative nausea-vomiting was evaluated with a 3-point system (0: no nausea and vomiting, 1: nausea, but no vomiting, 2: nausea with or without nausea) 24 hours postoperatively.	24 hours

External Links

•   British Journal of Surgery
•   European Journal of Anaesthesiology