Influenza in Human Clinical Trial
Official title:
Safety and Immunogenicity of Laser Assisted Epidermally Administered Seasonal Influenza Vaccine in Comparison to Intradermally Administered Seasonal Influenza Vaccine
It is the aim of the present study to compare the immunogenicity induced by a laser-assisted epidermally administered seasonal influenza vaccine to an intradermally administered seasonal influenza vaccine.
The skin is an attractive tissue for vaccination due to the impact of the cutaneous
micro-environment on the adaptive and non-adaptive immune responses. Conventionally many
vaccines are administered subcutaneously. Immune-competent cells however are not resident in
the subcutaneous fat tissue, but instead are located in the epidermis and the dermis of the
skin. Depending on the targeted skin layer and administration method, different immunological
outcomes are thus anticipated following vaccination.
In the present study, the immunogenicity (in terms of activation of B-cell mediated and
T-cell mediated immune responses) of laser-assisted epidermally administered seasonal
influenza vaccine will be compared to needle-based intradermal administration of the same
seasonal influenza vaccine.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04723771 -
Influenza Vaccine Effectiveness of a Quadrivalent Vaccine in Pregnant Women and Young Infants, 2019-2020
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