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Influenza, Human clinical trials

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NCT ID: NCT03367624 Recruiting - Influenza Clinical Trials

Epidemiology of Post-influenza Bacterial Pneumonia Due to a Panton-Valentine Leukocidin Positive Staphylococcus Aureus

FLUVALENTINE
Start date: October 1, 2017
Phase: N/A
Study type: Observational

Secondary bacterial influenza pneumonia caused by Panton-Valentine Leukocidin Positive Staphylococcus aureus is a rare complication but with poor prognosis. This pathology seems to affect young patients (20-40 years) without any medical history. Since the influenza pandemic of 2009, this complication is more and more mentioned, sought and diagnosed. However, the literature is poor, consisting of case reports, experimental studies on murine models, and low-power studies. The main objective is to evaluate the mortality in intensive care units of patients post-influenza bacterial pneumonia due to a Panton-Valentine Leukocidin positive Staphylococcus aureus

NCT ID: NCT03366402 Recruiting - Influenza A and B Clinical Trials

Sub Populations of Immune Cells in Influenza A and B Patients

Start date: January 2017
Phase: N/A
Study type: Observational

This study designed to examine changes of immune system cells sub-populations during influenza disease. Several parameters will be examined, such as: amount of sub populations, clinical parameters (body temperature and number of hospitalization days). The participants are children that are hospitalized in the Laniado hospital pediatric department.

NCT ID: NCT03365336 Recruiting - Influenza Clinical Trials

Influenza Management With Polyherbal Formulation

Start date: February 1, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to determine the efficacy of Flu care polyherbal formulation in the management of acute uncomplicated case of Influenza within 48 hours of symptoms onset.

NCT ID: NCT03357263 Completed - Influenza, Human Clinical Trials

A Study to Evaluate the Safety and Efficacy(Immunogenicity) of GC3114 in Healthy Adults

Start date: November 20, 2017
Phase: Phase 1
Study type: Interventional

Healthy adults will be once administered GC3114A(High-dose Quadrivalent influenza vaccine) or GCFLU Quadrivalent Pre-filled syringe inj..

NCT ID: NCT03346772 Recruiting - Clinical trials for Influenza Vaccination

Study of Immune Responses to Influenza Vaccination

Start date: October 20, 2017
Phase: Phase 4
Study type: Interventional

Better understanding of the immune responses to influenza vaccination is needed in order to understand situations of poor vaccine response. Adults will receive influenza vaccination and then have peripheral blood drawn at pre-defined intervals in order to study the lymphocyte responses.

NCT ID: NCT03345043 Completed - Influenza Clinical Trials

Safety, Tolerability, and Immunogenicity of VAL-339851 in Healthy Adult Subjects

Start date: May 11, 2016
Phase: Phase 1
Study type: Interventional

This clinical study will assess the safety, tolerability and immunogenicity of VAL-339851 in healthy subjects.

NCT ID: NCT03344029 Completed - Influenza Clinical Trials

Immunogenicity and Safety of the Shenzhen Trivalent Inactivated Influenza Vaccine Versus a Trivalent Influenza Vaccine Comparator in Chinese Subjects 18 to 59 Years

Start date: November 3, 2017
Phase: Phase 4
Study type: Interventional

This was a blind-observer, monocenter, randomized, comparative, Phase IV study designed to evaluate the immunogenicity and safety of the Sanofi Pasteur Shenzhen Trivalent Influenza Vaccine (SP Shz TIV) versus the Trivalent Influenza Vaccine manufactured by Hualan Biological Engineering Inc (Hualan TIV) comparator in healthy Chinese participants aged 18 to 59 years.

NCT ID: NCT03339180 Active, not recruiting - Influenza, Human Clinical Trials

Cardiac Injury in Patients With Influenza

Start date: October 1, 2017
Phase:
Study type: Observational

This study investigate the prevalence of elevated biomarkers of cardiac injury in patients with suspected influenza infection and the prognostic implication on the composite endpoint of death of any cause, hospitalization due to myocardial infarction, unstable angina, heart failure and stroke.

NCT ID: NCT03336619 Completed - Influenza Clinical Trials

A Phase III, Randomized, Double-Blind, Placebo Controlled Trial to Evaluate the Efficacy and Safety of Nitazoxanide in the Treatment of Uncomplicated Influenza

Start date: January 17, 2018
Phase: Phase 3
Study type: Interventional

Trial to evaluate efficacy and safety of nitazoxanide (NTZ) in the treatment of uncomplicated influenza.

NCT ID: NCT03332992 Completed - Influenza, Human Clinical Trials

Comparative Tests of Flu Vaccination Phone Messages

Start date: November 11, 2017
Phase: N/A
Study type: Interventional

This project is a partnership between Emmi Solutions, a private company that delivers health promotion messages to employees of client organizations, and the University of Michigan and affiliated academic investigators. In particular, Emmi sends out pre-recorded and interactive telephone calls on behalf of their healthcare clients to promote influenza vaccination each Fall. The collaboration will design various scripts (based on established risk communication, behavior change, and behavioral economic principles) to be pre-recorded and sent out on these calls on a randomized basis (with approval by client organizations), with the number of arms to vary based on the size of each client's participant list (to ensure sufficient statistical power within each client's sample). Emmi will deliver the calls and track individual responses to questions posed during the call. Emmi will then provide a de-identified dataset to the academic research team for analysis to determine whether any scripts provided greater or lesser effects to people's their motivations to get a flu vaccination.