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Biomarkers Predicting Infectivity in an Experimental Human Influenza Model — PRESAGE  

Influenza A Clinical Trial

Official title:
Biomarkers Predicting Infectivity in an Experimental Human Influenza Model

Clinical Trial Summary

This study aims to test the hypothesis that gene transcriptional changes occur within 24 hours of virus exposure in the blood and nasal mucosa, and to identify early biomarker signatures that are predictive of higher viral shedding at the peak of disease

Clinical Trial Description

This study will systematically investigate the early pre-symptomatic period following exposure to influenza in humans. The data obtained will be essential for further understanding of the natural history of human antiviral responses, and will allow us to identify a panel of biomarkers that can predict which individuals will go on to more severe symptoms and higher viral shedding, so that treatments and other interventions can be made at an early stage. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03207152
Study type Interventional
Source Duke University
Contact
Status Enrolling by invitation
Phase Phase 1
Start date September 11, 2017
Completion date February 28, 2019
View Details
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