Influenza A Virus/H5N1 Subtype Clinical Trial
Official title:
Host Genetic Susceptibility to Avian Influenza A/H5N1 in Vietnam, Thailand, Indonesia and Singapore
The identification and characterization of susceptibility loci for H5N1 infection in humans
could have profound implications. The detection of host genetic factors may shed light on
key pathogenic interactions between H5N1 and human cells, assisting in identifying the viral
characteristics determining pandemic potential. In addition, the identification and
verification of susceptibility loci would be followed by functional studies which might
point the way to new therapeutic and preventive options.
The objective of this study is to investigate if host genetic factors are associated with
susceptibility to influenza H5N1 illness
This is primarily an hypothesis screening exercise and while guesses based on biological
plausibility are possible, a comprehensive analysis of genetic susceptibility can only be
achieved by a whole genome approach. Therefore we will test for genetic linkage and
association using a large number of Single Nucleotide Polymorphisms (SNPs) spanning the
whole genome.
Principal Investigators have access to information on all surviving and deceased laboratory
confirmed H5N1 cases. These cases will form the study base. The epidemiologist will attempt
to make telephone contact with either the recovered patient or,if the patient died, the
closest relative of the deceased patient. The proposed study will be explained and
permission will be sought for the epidemiologist and a study nurse to visit the household to
explain the study in greater detail, to offer an opportunity for questions and, if the
subject agrees, to obtain informed consent for participation. If the epidemiologist has
difficulty in making contact with the case or their family the local public authorities will
be asked to assist in making contact. Eligible family members of H5N1 cases will be
identified by face-to-face interviews with the surviving confirmed cases or close family
members of deceased cases.
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Observational Model: Family-Based, Time Perspective: Cross-Sectional