Influenza A Virus, H1N1 Subtype Clinical Trial
Official title:
Study of Immune Responses After Vaccination Against Seasonal Influenza Virus and Against Influenza H1N1-v Pandemic Virus in a Clinical Staff (FLU-HOP)
This project may help to answer several fundamental questions related to public health
regarding vaccination against influenza viruses and regarding the influenza A(H1N1)v
pandemy:
What is the immunologic efficacy in terms of antibodies response of the vaccination against
the seasonal (2009-2010) influenza virus and against the A(H1N1)v virus in the clinical
staff?
Moreover, it may help to answer questions related to the use of a vaccine against influenza
virus variants emerging in the French population:
1. Before the vaccination:
- What is the status of the residual anti-H1N1 seasonal viruses immunity and of the
anti-A(H1N1)v immunity in the population stratified by age and taking into account
the multiplicity of the prior seasonal vaccinations?
- What is the level of the cellular and humoral cross-reactivity between the
different H1N1 strains?
2. After the vaccination:
- What is the intensity of the anti-vaccine immune response as a function of the age
of the population ad of the prior seasonal vaccinations?
- What is the level of the cellular and humoral cross-reactivity after vaccination
as a function of the age of the population and of the multiplicity of the prior
seasonal vaccinations?
n/a
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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