Influenza Clinical Trial
Official title:
Kinetics of the Immune Response to Inactivated Influenza Vaccine in Healthy Adults
The purpose of this study is to evaluate the body's immune response at different time points to an FDA-approved seasonal influenza vaccine. By better understanding the way the immune system responds to the influenza vaccine, the investigators can design more effective vaccines against influenza.
This is an observational study of seasonal, cell-cultured inactivated influenza vaccine
(cc-IIV4) in healthy males and non-pregnant females aged 18 to 45 years old, inclusive. This
clinical study is designed to comprehensively evaluate the characteristics and kinetics of
the immune response to influenza vaccine.
By developing a comprehensive understanding of the mechanisms by which the immune system
responds to influenza vaccine, including innate immune system responses, the effect of early
influenza exposures, and (eventually) the effect of potent adjuvants, the investigators will
be better equipped to design more highly effective vaccines to conquer seasonal influenza and
prevent influenza pandemics.
Data from this pilot observational study will guide the design of global studies addressing
age-specific responses, the impact of sex and geography, and the role of adjuvants on
influenza immunity.
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