Inflammatory Response Clinical Trial
Official title:
Sevoflurane Versus Propofol: A Comparision on Stress Response in Patients Undergoing Elective Lombar Disc Surgery
Stress is defined as hormonal and metabolic changes in the biological system that follow any injury. The stress response occurs as a general systemic response to injury and includes a wide range of endocrinological, immunological and hematological effects. The level of stress in the surgical process can affect not only the patients outcome but also the overall health system. The two main agents used in maintenance for general anesthesia are inhalation and intravenous anesthetics. Both inhalation anesthesia and TIVA (Total Intravenous Anesthesia) approaches provide general anesthesia suitable for surgical operations. However, the mechanisms of action of these two methods differ and are not fully understood. The aim of investigators' for this study was to investigate the effect of different anesthetic agents on stress inflammatory response in the preoperative, peroperative and postoperative periods.
Status | Not yet recruiting |
Enrollment | 40 |
Est. completion date | June 5, 2024 |
Est. primary completion date | June 5, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: - Extruded disc - Motor deficit - L4-5, L5-S1 levels disc herniation - 18-65 years - ASA I-II Exclusion Criteria: - Recurrence disc operation - Narrow channel - Trauma - Infection - Endocrine disease |
Country | Name | City | State |
---|---|---|---|
Turkey | University of Health Science, Kartal Dr Lutfi Kirdar Training and Researh Hospital | Istanbul |
Lead Sponsor | Collaborator |
---|---|
Dr. Lutfi Kirdar Kartal Training and Research Hospital |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | compare inflammatory markers with sevolurane and propofol : glucose, WBC, procalcitonin, CRP, erytrocyte sedimentation rate, ferritin, pre albumin, albumin,tranferrin | The primary aim of investigators' for this study was to compare the effect of different anesthetic agents on stress inflammatory response in the preoperative, peroperative and postoperative periods. | preoperative, intraoperative, postoperative 12-24 h (an average of 3 months) |
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