Hop Compounds and Immune System

Inflammatory Response Clinical Trial

— HI  

Official title:

Effect of Iso-alpha-Acids and Xanthohumol on Inflammatory Processes in Human

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04847193
• Other study ID #: UVienna19a
• Status: Completed
• Phase: N/A
• Start date: June 13, 2019
• Est. completion date: January 27, 2021

Study information

• Verified date: March 2022
• Source: University of Vienna
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of the present study is to determine the effect of Xanthohumol and Iso-alpha-acids from hops on the immune response of healthy participants.

Description:

In this placebo-controlled crossover study a study drink enriched with either a placebo, Xanthohumol, Iso-alpha Acids or a combination of latter is given to the participants. A washout phase before intervention and between each intervention is introduced. On day one of each intervention blood is drawn in fasted state from each participant. Subsequently the study drink combined with a standardized breakfast is given to the participants following a second blood drawing one hour after the consumption of the study drink. On the last day of each intervention blood is taken from study participants in the same manner as on day one. To assess the effect of Xanthohumol and Iso-alpha acids or a combination of both, clinical chemical parameters e.g. ALT, AST, γ-GT, blood lipids (triglycerides, total cholesterol, HDL, LDL), blood glucose, uric acid and CRP are determined. Furthermore, PBMC's isolated from blood samples of each time point were stimulated for either 24 or 48 h. Protein levels and mRNA expression of markers of inflammation is measured in PBMC's and supernatant of stimulated cells.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15
• Est. completion date: January 27, 2021
• Est. primary completion date: January 27, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• healthy, normal weight,

Exclusion Criteria:

• food intolerances, food allergies, chronic inflammatory diseases, metabolic diseases, viral or bacterial infections within the last 3 weeks of inclusion, intake of immunosupressive medication

Related Conditions & MeSH terms

• Inflammatory Response

Intervention

Other:
• Dietary Intervention 1: Placebo
Participants receive a study drink supplemented with a placebo for 5 days
• Dietary Intervention 2: Xanthohumol and Iso-alpha acids
Participants receive a study drink supplemented with xanthohumol, Iso-alpha acids or a combination of both for 5 days

Locations

Country	Name	City	State
Austria	University of Vienna	Vienna

Sponsors (1)

Lead Sponsor	Collaborator
University of Vienna

Country where clinical trial is conducted

Austria, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in parameters of immune response	Parameters of immune response are measured in cell culture supernatant of stimulated cells	5 days