Influence of of a Lipid Emulsion on Inflammatory Response & Hepatic

Status Completed

Clinical Trial Summary

Lipid emulsions are an essential part of parenteral nutrition, both as a part of energy supply, and as a source of essential fatty acids. It has been shown that the fatty acid composition of cell membranes is influenced by the fatty acid profile of dietary lipids, and may therefore be responsible for modulation of immune response. The aim of this study was to assess the effects of a new lipid emulsion based ob soybean oil, medium-chain triglycerides, olive oil and fish oil compared with a lipid emulsion based on olive and soybean oil on the inflammatory response and hepatic function in postoperative intensive care unit (ICU) patients.

Clinical Trial Description

Fatty emulsions are an indispensable part of parenteral nutrition, because they deliver energy and essential fatty acids. Furthermore, lipids are involved in the structure and function of cell membranes and receptors, modifying gene expression, and modulating the inflammatory and immune response. In addition, fatty acids are precursors of prostaglandins and other eicosanoids and have therefore important metabolic functions.A promising substrate in the development of lipid emulsions can be seen in fish oils containing solutions. With regard to the current literature, fish oil have a potential benefical influence on the pathophysiological response to endotoxins and exert important modulations on eicosanoid and cytokine biology.

However, there are no studies avaibale comparing fish oil containing fatty emulsions to a lipid emulsion based on olive and soybean oil with regard to inflammatory response and hepatic function.

Therefore, the aim of this study was to evaluate the effects of a new lipid emulsion based ob soybean oil, medium-chain triglycerides, olive oil and fish oil compared to a lipid emulsion based on olive and soybean oil on the inflammatory response and hepatic function in postoperative intensive care unit (ICU) patients. ;

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00600912
Study type	Interventional
Source	Klinikum Ludwigshafen
Contact
Status	Completed
Phase	Phase 4
Start date	December 2006
Completion date	December 2007

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04496154` - Omega-3 to Reduce Diabetes Risk in Subjects With High Number of Particles That Carry "Bad Cholesterol" in the Blood	N/A
Not yet recruiting	`NCT06434701` - Severe COVID-19 Infection in Children Presenting to EDs in Israel and England	N/A
Enrolling by invitation	`NCT05020210` - Effect of Early Treatment With Sivelestat Sodium in ARDS Patients
Completed	`NCT04084301` - Impact of Cardiopulmonary Bypass Flow on Renal Oxygenation, Blood Flow and Tubular Injury	N/A
Completed	`NCT04597983` - Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists	N/A
Not yet recruiting	`NCT06016023` - Evaluation of Macrophage Inflammatory Protein-1α as a Periodontal Disease Biomarker
Not yet recruiting	`NCT05990933` - Role of Adrenaline in in the Inflammatory Response in Diabetes	N/A
Not yet recruiting	`NCT04608643` - Inflammatory Markers and Cbc Indices in Severely Malnourished Children
Recruiting	`NCT01934049` - Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty	Phase 4
Recruiting	`NCT01417923` - The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain	Phase 4
Terminated	`NCT01377441` - Effect of Intravenous Ibuprofen on Inflammatory Responses in Patients Undergoing Surgery With General Anesthesia.	Phase 4
Completed	`NCT01301079` - Evaluation of the Effect of Ketamine on Remifentanil-induced Hyperalgesia	Phase 3
Terminated	`NCT00578578` - Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels	Phase 4
Recruiting	`NCT04611334` - The Effects of HRV Biofeedback on Chronic Kidney Disease Patient.	N/A
Recruiting	`NCT03510702` - SCREENING OF EPIGENETIC BIOMARKERS (miRNAs) IN THE GINGIVAL SULCUS
Completed	`NCT03445234` - Blueberries, Bananas, Exercise Recovery	N/A
Not yet recruiting	`NCT06450704` - Cerebral and Anti-inflammatory Response Through Exercise - Mechanisms In Depressive Disorders	N/A
Not yet recruiting	`NCT05754294` - Electric Polarization of Red Blood Cells : A Cohort Study to Assess the Erythrocytes Membrane Integrity Through Charge Conservation, Following Cardiac Surgery.
Not yet recruiting	`NCT04386525` - Omega 3 and Ischemic Stroke; Fish Oil as an Option	Phase 4
Completed	`NCT04864600` - CANDLE - A Study of Acute Health Effects of Exposure to Particles Generated by Candles	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Influence of of a Lipid Emulsion on Inflammatory Response and Hepatic Function

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms