Periodontal Diseases Clinical Trial
Official title:
The Effectiveness of Hydroxylated Polymethoxy Flavones Solid Dispersion Incorporated Sodium Carboxymethyl Cellulose Gel With Periodontal Debridement in the Treatment of Periodontitis. Clinical- Biochemical Study
Periodontitis is a serious gum infection that damages the soft tissue and, without treatment, can destroy the bone that supports your teeth. Hydroxylated poly methoxy flavones are a combination of naturally occurring flavonoids extracted from the orange peel and exert anti-inflammatory, antibacterial, and antifungal activity however, this extract is poorly soluble and poorly absorbable. In this work, this extract was formulated as a solid dispersion formulation to enhance its biological activity and then incorporated into a gel base and used in the treatment of periodontitis after clinical debridement.
In the study, there are 3 groups; the first one first one received plain sodium carboxymethylcellulose. Group II received chlorhexidine gel. GroupIII received Hydroxylated poly methoxy flavones solid dispersion incorporated into sodium carboxymethylcellulose gel. In all groups, there is clinical debridement before injection of gels. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04712630 -
Non-Incised Papillae Surgical Approach (NIPSA) With and Without Graft
|
N/A | |
Recruiting |
NCT03997552 -
NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration
|
N/A | |
Completed |
NCT04478864 -
Knowledge, Practice and State of Periodontal Health
|
||
Completed |
NCT03507868 -
YKL-40 and IL-6 Levels in Periodontal Disease
|
||
Completed |
NCT05720481 -
Impact of Periodontal Treatment on Growth Differentiation Factor-15 Levels
|
N/A | |
Recruiting |
NCT06052150 -
Oral Health In Cirrhosis of the Liver (ORACLE)
|
||
Recruiting |
NCT06025955 -
Evaluation of Outcomes of Minimally Invasive Non- Surgical Versus Surgical Therapy in Furcation Involvement.
|
N/A | |
Recruiting |
NCT03510702 -
SCREENING OF EPIGENETIC BIOMARKERS (miRNAs) IN THE GINGIVAL SULCUS
|
||
Completed |
NCT05631600 -
Manuka Honey as an Adjunct to Non-surgical Periodontal Therapy: Clinical Study
|
Phase 2/Phase 3 | |
Active, not recruiting |
NCT05068778 -
Development of an AI App to Improve Compliance in Periodontal Maintenance Patients
|
||
Not yet recruiting |
NCT05178563 -
Mechanisms of Acute Inflammation Following Periodontal Treatment
|
N/A | |
Recruiting |
NCT06224699 -
Toothpaste With Sodium Carbonate in Patients With Gingivitis
|
N/A | |
Recruiting |
NCT06086821 -
Clinical Relevance of Different Time of Periodontal Re-evaluation
|
N/A | |
Not yet recruiting |
NCT05721313 -
Vital Root Amputation in Molars With Advanced Periodontal Furcation Involvement: a Preliminary Study
|
N/A | |
Completed |
NCT06040944 -
Antipsychotic Induced Hyperprolactinemaia as Risk Factor for Periodontitis in Schizophrenic Patients
|
||
Completed |
NCT06306937 -
Serum Levels of Vitamin D and IL8 in Patients With Periodontitis
|
||
Recruiting |
NCT04669717 -
Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies
|
Phase 4 | |
Completed |
NCT05576142 -
Oral Findings in Pediatric Patients With Allergic Rhinitis and/or Asthma
|
||
Completed |
NCT03694496 -
The Effectiveness of an Oral Health Education Programme of Adolescents in Hong Kong
|
N/A | |
Not yet recruiting |
NCT03588507 -
Clinical and Radiographic Evaluation of PPF With or Without NCHA Bone in Treatment of Intrabony Defects
|
N/A |