Inflammatory Disease clinical trials

Inhaled Nanosilver Study

Background: - Nanosilver is tiny silver particles. Many products contain nanosilver, like antimicrobial cleaning supplies and antimicrobial fabrics. Some products also contain nanosilver in a solution that people inhale. The companies that make these products claim they can help boost the immune system. Objective: - To learn if inhaling nanosilver affects the lung s immune system. In addition, to see if nanosilver affects lung function and if it gets absorbed into the bloodstream after it is inhaled. Eligibility: - Healthy, non-smoking adults ages 18 60. Design: - Participants will be pre-screened by phone. - Participants will then be screened with a medical history and physical exam. They will give blood and urine samples. - Participants will have lung function tests. They will breathe into a spirometer. It has a mouthpiece attached to a tube that is connected to a computer. - Participants will have a methacholine challenge test. They will blow into a spirometer. Then they will inhale methacholine. - Eligible participants will have 3 study visits over 2 5 weeks. At each visit, they will repeat some of the screening tests. - At visit 1, participants will have a bronchoscopy. For this, an intravenous line is placed in an arm vein. Electrodes are placed on the chest. A tube is placed through the nose and into the airways. The airway is washed. A sample of cells is taken. - At visit 2, participants will get the study treatment. They will inhale a nanosilver solution mist. They will have lung function tests before and after treatment. - Participants will collect their urine from the time they get the treatment until they return to the clinic the next day. - At visit 3, participants will turn in their urine. They will have another bronchoscopy.