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Validation of a Preclinical Model Based on Patient-derived Organoids for the Study of the Gut-joint Axis in Spondyloarthritis — ORGANOSPA  

Inflammatory Bowel Diseases Clinical Trial

Official title:
Validation of a Preclinical Model Based on Patient-derived Organoids for the Study of the Gut-joint Axis in Spondyloarthritis

Clinical Trial Summary

This project aims to develop and validate a model of human organoids derived from patients with Spondyloarthritis, focusing on synovial and intestinal tissues as targets of the gut-joint axis. The tissue marker profile of patient-derived organoids studied by gene expression, immunohistochemistry, and cytokine production profile will be compared with that of controls in order to test for the presence of specific biomarkers.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06421116
Study type Observational
Source Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Contact Maria Antonietta D'Agostino, Professor
Phone +390630157807
Email mariaantoniettadagostino@policlinicogemelli.it
Status Recruiting
Phase
Start date March 7, 2024
Completion date December 31, 2025
View Details
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