Thalidomide Therapy for VEOIBD

Status Not yet recruiting

Clinical Trial Summary

This is a single center, observational study to investigate the clinical outcomes of thalidomide treatment for very early onset inflammatory bowel disease

Clinical Trial Description

Very early onset inflammatory bowel disease (VEOIBD) refers to IBD diagnosed before 6 years of age. VEOIBD comprises a distinct subset of pediatric IBD characterized by stronger genetic predisposition, predominant colonic involvement, more extensive inflammation, more severe course, and peculiar response to treatments. Previous studies have been demonstrated that thalidomide, an oral molecule with immunomodulatory, antiangiogenic, and TNF-suppressing properties, is an effective and safe treatment for adults and children with IBD refractory to conventional therapies. This study is aimed to evaluate the efficacy and tolerance of thalidomide in VEOIBD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06382519
Study type	Observational
Source	Children's Hospital of Fudan University
Contact	Ying Huang
Phone	021-64931727
Email	yhuang815@163.com
Status	Not yet recruiting
Phase
Start date	May 15, 2024
Completion date	December 31, 2026

View Details

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