Metformin as Added on Therapy in Patients With Ulcerative Colitis

Status Recruiting

Clinical Trial Summary

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is marked by increased intestinal motility and bloody diarrhea. The clinical value of existing therapeutic strategies of UC, including glucocorticoids, anti-tumor necrosis factor α (TNF-α), mesalamine, and thiopurines is still limited. Therefore, the discovery of new therapeutic approaches is essential to improve the effectiveness of the treatment.Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a conserved fuel-sensing enzyme that plays an important role in the regulation of cellular metabolism where it increases glucose and fatty acids uptake and activates the oxidation process to improve the cellular energy utilization

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05574387
Study type	Interventional
Source	Tanta University
Contact	Mostafa Bahaa, PhD
Phone	0201025538337
Email	mbahaa@horus.edu.eg
Status	Recruiting
Phase	Phase 2
Start date	January 20, 2023
Completion date	April 2027

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