Based on the Special Disease Management of Crohn's Disease Diet Studies

Inflammatory Bowel Diseases Clinical Trial

Official title: Based on the Special Disease Management of Crohn's Disease Diet Studies --a Multicenter, Randomized, Controlled and Open Label Study

Status Recruiting

Clinical Trial Summary

This project plans to develop a new diet therapy suitable for China -- CD-C-food, which is more in line with the common diet of Chinese patients' eating habits and economic conditions, and its expected therapeutic effect and influence on intestinal microorganism are similar to that of EEN. In order to explore the influence of intestinal microorganisms and their metabolites on the clinical remission effect and inflammatory response of patients with CD-C-Food, and to reveal the possible internal mechanism， a randomized control of adult subjects with a healthy CD-Chinese-food diet, treatment group of CD patients and animal model will be conducted by using intestinal microbiome, bacterial metabolite analysis, inflammatory factors detection and other technical means.

Clinical Trial Description

Exclusive Enteral Nutrition (EEN) is the only established dietary treatment for children with CD.Changes in diet affect the amount of short-chain fatty acids and branched-chain fatty acids produced by changing the composition of intestinal flora, leading to changes in intestinal state.Through the long-term clinical observation of our team, most patients with CD can achieve stable remission by removing the processed food and screening the corresponding food by combining the characteristics of Chinese diet with the food intolerance detection method. So, what kind of diet is suitable for the treatment of CD patients in China? The CD-Treat program, replacing the Western diet with Chinese diet, so as to design an individualized program CD-Chinese-food (CD-C-food) that is consistent with the eating habits of Chinese patients with CD. By comparing the effects of this individualized diet with EEN on inducing and maintaining remission in CD patients. ;

Related Conditions & MeSH terms

• Crohn Disease
• Inflammatory Bowel Diseases

• NCT number: NCT04976491
• Study type: Observational [Patient Registry]
• Source: Second Affiliated Hospital, School of Medicine, Zhejiang University
• Contact: Qiao Yu, PhD
• Phone: 13456820567
• Email: yuqiao@zju.edu.cn
• Status: Recruiting
• Start date: August 1, 2020
• Completion date: December 1, 2023