Inflammatory Bowel Diseases Clinical Trial
Official title:
Lymphoid Tyrosine Phosphatase Gene Polymorphisms in Inflammatory Bowel Disease
This study aims:
1. To investigate the association between single nucleotide polymorphisms of PTPN22 gene
(rs2476601, rs33996649 and rs2488457) and inflammatory bowel disease.
2. To correlate the relation between the studied SNPs and disease activity /response to
therapy.
Status | Not yet recruiting |
Enrollment | 200 |
Est. completion date | September 2021 |
Est. primary completion date | May 2021 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility |
Inclusion Criteria: - patients with inflammatory bowel disease Exclusion Criteria: - Patients with systemic autoimmune diseases (RA,SLE) will be excluded from the study . |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Assiut University |
Norouzinia M, Chaleshi V, Alizadeh AHM, Zali MR. Biomarkers in inflammatory bowel diseases: insight into diagnosis, prognosis and treatment. Gastroenterol Hepatol Bed Bench. 2017 Summer;10(3):155-167. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Association between single nucleotide polymorphisms of Lymphoid Tyrosine Phosphatase gene (rs2476601, rs33996649 and rs2488457) and inflammatory bowel disease | Three single nucleotide polymorphisms in the lymphoid tyrosine phosphatase gene(SNP (G788>A) in exon10, SNP (C1858>T) in exon 14 and SNP (G -1123>C) in the promoter region ) will be assessed in 100 patients diagnosed as inflammatory bowel disease and 100 healthy subjects by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) to detect association between these polymorphisms and inflammatory bowel disease | baseline | |
Secondary | To correlate the relation between the studied SNPs and disease activity /response to therapy. | Serum Erythrocyte Sedimentation Rate ,C-Reactive Protien ,Anti Nuclear Antibody ,Antineutrophil Cytoplasmic Antibody (ANCA) and Anti Saccharomyces Cerevisiae (ASCA) and fecal calprotectin will be done to all patients.The three investigated polymorphisms in LYP will be correlated with the markers of disease activity and IBD patients response to therapy. | baseline |
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