The Bacterial Secretome in IBD

Status Recruiting

Clinical Trial Summary

Secreted bacterial effectors produced by the intestinal microbiota are in part responsible for the proinflammatory effect of the fecal content in inflammatory bowel disease (IBD) patients.

Clinical Trial Description

Fecal colonic content will be collected by suction during routine colonoscopy. From the fecal content different fractions (containing soluble bacterial fractions and membrane bound bacterial fractions) will be processed. These bacterial fractions (also termed as bacterial secretome) will be tested for proinflammatory potential in tissue culture assays including epithelial colonic cell lines and dendritic/monocytic cell lines. The main outcome parameter will be the secretion of proinflammatory cytokines from the tissue culture. For this purpose the investigators will test different groups of patients including patients with active/inactive Crohn's disease or ulcerative colitis, patients with other inflammatory conditions of the colon, patients with colorectal carcinoma and healthy controls undergoing colonoscopy. ;

Study Design

Related Conditions & MeSH terms

Inflammatory Bowel Diseases

Clinical Trial Details

NCT number	NCT04136587
Study type	Interventional
Source	Medical University of Graz
Contact	Christoph Hoegenauer, Prof
Phone	004331638581786
Email	christoph.hoegenauer@medunigraz.at
Status	Recruiting
Phase	N/A
Start date	June 1, 2019
Completion date	December 2025

View Details

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