Inflammatory Bowel Diseases Clinical Trial
Official title:
Assessment of Inflammation Load, Endothelial and Cardiac Function Before and After Medical and Surgical Treatment in Inflammatory Bowel Diseases
The aim of this study is to compare medical and surgery treatment in IBD patients and healthy controls, by assessing the endothelial and cardiac function and the inflammation status.
The aim of this study is to compare medical and surgery treatment in IBD patients and healthy
controls, by assessing the endothelial and cardiac function and the inflammation status.
In particular, three subject groups will be enrolled, as follows:
40 patients [Crohn's disease (CD) & ulcerative colitis (UC)] who will undergo medical
treatment (Group A), 40 patients (CD & UC) who will undergo surgery (Group B) and a healthy
control group (Group C) comprising 40 subjects.
Assessment of the inflammation load (CRP, WBC, IL-6, TNFa), the endothelial function (FMD,
PWV, cIMT, endothelial glycocalyx) and the cardiac function - via echocardiographic
parameters (systolic and diastolic echo values, tissue doppler imaging-GLS-strain rate) -
will be carried out for every subject group in two phases: prior to treatment and four months
after the treatment, as applicable.
The objective is to investigate whether there is a statistically significant reduction of
endothelial and cardiac dysfunction following medical and surgery treatment in IBD patients
as well as to examine associations across the three groups.
;
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