Inflammatory Bowel Diseases Clinical Trial
— COSMICOfficial title:
Characterization of Mesenchymal Stem Cells From the Colon and Small Intestine of Patients With Inflammatory Bowel Disease - The COSMIC Study
Verified date | December 2021 |
Source | University Hospital, Montpellier |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The exact origin of inflammatory bowel disease (IBD) is still unknown. The current hypothesis is that IBD is secondary to an abnormal intestinal immun response directed to all or part of the intestinal flora in genetically predisposed individuals. Several experimental studies have demonstrated the ability of mesenchymal stem cells (MSCs) from bone marrow or adipose tissue origin to control intestinal inflammation in animal models. However, to date, there are no data regarding the functions of resident MSCs in the colon and small intestine of IBD patients. We hypothesize that dysfunction of resident intestinal MSCs contributes to the disruption of intestinal homeostasis in patients with IBD causing the development of intestinal inflammation. The aim of this research project is to identify, describe and characterize at the molecular and functional level MSCs of the colon and small intestine of patients with Crohn's disease and ulcerative colitis and to compare them with a control population.
Status | Terminated |
Enrollment | 2 |
Est. completion date | February 13, 2019 |
Est. primary completion date | February 13, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 75 Years |
Eligibility | Inclusion criteria: - For IBD patients : - Age between 18 and 75 year old - Diagnosis of Crohn's disease or ulcertaive colitis according to internationla guidelines - Endoscopically active disease - Indication for colonoscopy or intestinal resection according to standard of care - Written inform consent - For control patients : - Age between 18 and 75 year old - Indication for screening colonoscopy for irritable bowel syndrome, diverticulum or colorectal cancer surveillance according to standard of care - Indication for intestinal resection for diverticulum or colorectal cancer according to standard of care - Written inform consent Exclusion criteria: - For IBD patients : - Active intestinal infection - Confirmed intestinal parasitosis - Intestinal stoma - For control patients : - Active intestinal infection - Confirmed intestinal parasitosis - Intestinal inflammation at colonoscopy - Chronic intestinal inflammation on biopsies - Absence of healthy tissue on surgical specimen |
Country | Name | City | State |
---|---|---|---|
France | Hopital St Eloi | Montpellier |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Montpellier |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Proliferation and differentiation of intestinal MSCs in IBD patients. | Proliferation and differentiation of intestinal MSCs in IBD patients. | 1 month | |
Secondary | Comparison of MSCs between IBD patients and control patients | Comparison of MSCs between IBD patients and control patients using mmunohistochemistry, immunofluorescence, quantification of pro- and anti-inflammatory cytokines production. | 1 month |
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