Inflammatory Bowel Diseases Clinical Trial
— NT-pro-MICIOfficial title:
Evaluation of NT-proBNP in Chronic Inflammatory Bowel Disease
Verified date | July 2020 |
Source | Centre Hospitalier Universitaire, Amiens |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
NT-proBNP is a major diagnostic and prognostic marker in cardiology, but it is also a new
marker for biological inflammation, especially in rheumatology.
Its evaluation in chronic inflammatory bowel disease was carried out in a preliminary study,
the OPERA study where in a population of 12 patients showed an increase in NT-proBNP
correlated with the biological and endoscopic activity of the disease. This larger study is
therefore a pilot study that could see NTproBNP as a new biomarker of inflammation in MICI.
Status | Terminated |
Enrollment | 159 |
Est. completion date | August 7, 2017 |
Est. primary completion date | August 7, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Adult subjects (age 18 years) - MICI Group: Patients monitored for probable HC or MC - Control group: Patients referred for consultation in gastroenterology with a clinical and endoscopic picture eading to the diagnosis of TF I - Person who agreed to participate in the study - Patient covered by social insurance Exclusion Criteria: - Causes of increased concentrations of natriuretic peptides: acute heart failure, acute or chronic pulmonary disease with right ventricular repercussion, valvulopathies, primary or secondary HVG, atrial fibrillation cardiac arrhythmia, chronic systolic dysfunction, hyperthyroidism, Addison's disease, hyperaldosteronism Primary, diabetes, cirrhosis with ascites, cancers, chronic renal insufficiency. - Inflammatory and autoimmune diseases (excluding MC and RCH), chronic inflammatory syndrome - Ongoing treatment that may affect the concentration of natriuretic peptides: ACE inhibitor, angiotensin II receptor antagonists, diuretics - Patient deprived of liberty or protected major (under guardianship or curatorship) |
Country | Name | City | State |
---|---|---|---|
France | CHU Amiens Picardie | Amiens | Picardie |
Lead Sponsor | Collaborator |
---|---|
Centre Hospitalier Universitaire, Amiens |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Blood level of NTproBNP. | 1 month |
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