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Johns Hopkins Crohn's Disease and Ulcerative Colitis Study

Inflammatory Bowel Disease Clinical Trial

Official title:
Johns Hopkins Crohn's Disease and Ulcerative Colitis Study

Clinical Trial Summary

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a idiopathic, chronic and frequently disabling inflammatory disorder of the intestines characterized by a dysregulated mucosal immune response that affect more than a million Americans. This current protocol was established in 1996 with the goal of identifying the genetic and environmental components that contribute to the development of IBD, especially in families.

Clinical Trial Description

We initiated this research study in 1996 with the overall goal of identifying IBD susceptibility genes. In the beginning, our major focus was recruitment of multiply affected IBD pedigrees for linkage studies, but we have since expanded our study to include singleton cases and spousal/friend as well as population controls for comparison purposes Our recruitment goal is 2500 subjects. Blood samples obtained from participants are used to isolate lymphocytes for storage, serum for serological analysis of antibodies and other proteins relevant to IBD and DNA for genotyping or sequencing. Lymphocytes may be transformed with EBV to establish immortalized lymphoblastoid cell lines. These cell lines can be used as a secondary DNA source or to study IBD relevant gene, protein expression and cell function ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01169207
Study type Observational
Source Johns Hopkins University
Contact
Status Active, not recruiting
Phase
Start date July 1996
Completion date December 2027
View Details
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