Gut Microbiota in the Healthy Population, Inflammatory Bowel Disease

Status Terminated

Clinical Trial Summary

The aim of this study is to compare the gut microbiota in Chinese patients with Inflammatory Bowel Disease (IBD) in Hong Kong with that of healthy controls, compare the gut microbiota in IBD patients in a developing country (low but increasing IBD incidence, Hong Kong) with those in a developed country (high incidence, Australia), compare the gut microbiota in Chinese patients with IBD in Hong Kong with the microbiota of their non-IBD affected parents and siblings.

Clinical Trial Description

Crohn's disease and ulcerative colitis are chronic inflammatory disorders of the gut that cause major life-long disability. Afflicting mostly young people at an age when they are most active both in their private and professional life, inflammatory bowel disease (IBD) represents an important public health problem affecting both the patients education, working abilities, social life and quality of life. Previously a disease predominantly of the West, there is now a marked increase in the incidence of IBD in Hong Kong. The cause of this dramatic increase over the last decade is unknown. Genetic factors, environmental factors and the gut bacteria may play a role in disease development. This study aims to explore the factors that may be contributing to, or causing, the rise of IBD in Hong Kong. The investigators propose to study the gut bacteria in Chinese patients with IBD compared with non-IBD patients, and healthy relatives of IBD patients. IBD patients will be prospectively recruited, blood samples will be obtained for serology and genotyping, stool samples and biopsies will be collected during routine colonoscopy for microbiota analysis. Bloods, stool and tissue gut microbiota from non-IBD patients will be collected for comparison. Studying gut microbiota, genetics and environmental factors in populations with changing incidence of IBD offers the greatest hope of identifying potentially important causative factors for disease. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01140802
Study type	Observational
Source	Chinese University of Hong Kong
Contact
Status	Terminated
Phase
Start date	April 2010
Completion date	January 2015

View Details

See also
Status	Clinical Trial	Phase
Withdrawn	`NCT03278912` - Natural History of Intestinal Inflammation in People With Primary Immune Dysregulations
Terminated	`NCT00061282` - Clotrimazole Enemas for Pouchitis in Children and Adults	Phase 1/Phase 2
Recruiting	`NCT05579392` - A Randomized Crossover Trial of Bright Light Therapy in Crohn's Disease on Intestinal Barrier Homeostasis	N/A
Completed	`NCT03264690` - Study to Observe the Change in Microbiome in Human Derived Sample and the Relation With Clinical Response Before and After the Anti-TNF Treatment in IBD Patients
Recruiting	`NCT02861053` - Inflammatory Bowel Disease : Could a Regular Physical Activity Reduce Patients Fatigue ?	N/A
Recruiting	`NCT02275676` - Resting Energy Expenditure and Nutritional Status in IBD	N/A
Completed	`NCT02503696` - Sample Collection Study to Evaluate DNA Markers in Subjects With Inflammatory Bowel Disease (IBD)	N/A
Completed	`NCT02161640` - Vascular Dysfunction in Paediatric IBD	N/A
Completed	`NCT02197780` - Head-to-head Comparison of Two Fecal Biomarkers to Screen Children for IBD	N/A
Completed	`NCT01933867` - Water-aided Colonoscopy in Inflammatory Bowel Disease Patients	N/A
Completed	`NCT01860651` - Web-based Monitoring in Children and Adolescents With Inflammatory Bowel Disease	N/A
Completed	`NCT01852760` - Assessment of Disease Activity in Ulcerative Colitis by Endoscopic Ultrasound	N/A
Completed	`NCT01688557` - Trial on Innovative Technologies in Colonoscopy	N/A
Completed	`NCT01692743` - Telemedicine in Patients With Inflammatory Bowel Disease (TELE-IBD)	Phase 3
Completed	`NCT01666535` - Infliximab IBD Influenza Vaccine Study	N/A
Completed	`NCT01676324` - FOCUS: The Future of Fecal Calprotectin Utility Study for the Diagnosis and Management of Inflammatory Bowel Disease (IBD)	N/A
Completed	`NCT01557387` - Real-time Diagnosis of Pseudopolyps During Colonoscopy
Completed	`NCT01981616` - Immune Response to Systemic and Mucosal Antigenic Challenge in the Presence of Vedolizumab	Phase 1
Completed	`NCT01476995` - Prognostic Indicators as Provided by the EPIC ClearView	N/A
Completed	`NCT01221818` - A Randomized, Double-Blind, Placebo-Controlled, Ascending Single Dose Study of E6007 in Healthy Subjects	Phase 1

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Gut Microbiota in the Healthy Population, Inflammatory Bowel Disease Patients, and Their Relatives

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms