Infective Endocarditis Clinical Trial
Official title:
The Predictive Value of Lubricin in Patients With Infective Endocarditis
Verified date | February 2024 |
Source | Aydin Adnan Menderes University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The main goal of this study is to evaluate the predictability of the disease by measuring the serum lubricin levels in patients with infective endocarditis and in non-patients
Status | Enrolling by invitation |
Enrollment | 60 |
Est. completion date | February 20, 2026 |
Est. primary completion date | February 20, 2024 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: - The patient must be between 18 and 65 years old - Patients diagnosed with infective endocarditis according to the Duke criteria Exclusion Criteria: - The patient being pregnant |
Country | Name | City | State |
---|---|---|---|
Turkey | Sevil Gulasti | Aydin | Zafer |
Lead Sponsor | Collaborator |
---|---|
Aydin Adnan Menderes University |
Turkey,
Delgado V, Ajmone Marsan N, de Waha S, Bonaros N, Brida M, Burri H, Caselli S, Doenst T, Ederhy S, Erba PA, Foldager D, Fosbol EL, Kovac J, Mestres CA, Miller OI, Miro JM, Pazdernik M, Pizzi MN, Quintana E, Rasmussen TB, Ristic AD, Rodes-Cabau J, Sionis A, Zuhlke LJ, Borger MA; ESC Scientific Document Group. 2023 ESC Guidelines for the management of endocarditis. Eur Heart J. 2023 Oct 14;44(39):3948-4042. doi: 10.1093/eurheartj/ehad193. No abstract available. Erratum In: Eur Heart J. 2023 Sep 20;: Eur Heart J. 2024 Jan 1;45(1):56. — View Citation
Holland TL, Baddour LM, Bayer AS, Hoen B, Miro JM, Fowler VG Jr. Infective endocarditis. Nat Rev Dis Primers. 2016 Sep 1;2:16059. doi: 10.1038/nrdp.2016.59. — View Citation
Rajani R, Klein JL. Infective endocarditis: A contemporary update. Clin Med (Lond). 2020 Jan;20(1):31-35. doi: 10.7861/clinmed.cme.20.1.1. — View Citation
Richendrfer H, Jay GD. Lubricin as a Therapeutic and Potential Biomarker in Sepsis. Crit Care Clin. 2020 Jan;36(1):55-67. doi: 10.1016/j.ccc.2019.08.005. Epub 2019 Oct 21. — View Citation
Solakyildirim K, Li Y, Bayer AS, Sullam PM, Xiong YQ, Lebrilla CB, Bensing BA. Proteoglycan 4 (lubricin) is a highly sialylated glycoprotein associated with cardiac valve damage in animal models of infective endocarditis. Glycobiology. 2021 Dec 18;31(11):1582-1595. doi: 10.1093/glycob/cwab095. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Valve damage indicative sign in infective endocarditis | Concentration of Lubricin parameter have a determinative role in patients with infective endocarditis | through study completion, an average of 2 years |
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