Clinical Trials Logo
  1. Home
  2. Infective Endocarditis
  3. NCT05446376

Contribution of PET/CT With Gallium 68 Citrate (68Ga-PET/CT) for the Diagnosis of Prosthetic Valve Infective Endocarditis — CiGal-EI-TEP  

Infective Endocarditis Clinical Trial

Official title:
Contribution of PET/CT With Gallium 68 Citrate (68Ga-PET/CT) for the Diagnosis of Prosthetic Valve Infective Endocarditis

Clinical Trial Summary

CiGal-EI-TEP is an exploratory study that aim to assess the diagnostic performance of 68Ga Positron emission tomography (PET) / Computed Tomography (CT) for the diagnosis of prosthetic valve infective endocarditis in comparison with the final diagnosis established according to the ESC 2023 criteria, after 3 months of follow-up, by a panel of experts.

Clinical Trial Description

Diagnosis of prosthetic valve infective endocarditis is challenging. It is based on the modified criteria of the European Society of Cardiology (ESC) 2023 which include clinical, microbiological and imaging data. 18F-fluorodeoxyglucose (18FDG) PET/CT is a major diagnostic criterion for prosthetic valve infective endocarditis. In practice, 18FGD-PET/CT is carried out as soon as possible in all patients having valve repair materials and suspected of infective endocarditis on material. According to studies, the sensitivity of 18FDG-PET/CT is around 80% for the diagnosis of infective endocarditis on a prosthetic valve. The use of 18FDG requires a low carbohydrate diet the day before the exam. Compliance with this condition is difficult to obtain, in diabetic patients. Without following these instructions, interpretation of the heart valves is difficult, and this can leed to false negatives. The use of an another radiopharmaceutical drug could avoid these problem. PET/CT with Gallium 68 citrate (68Ga-PET/CT) could reduce the number of false negatives while having similar specificity to 18FDG-PET/CT for the diagnosis of infective endocarditis on prosthetic valve. The investigators therefore propose an exploratory study to assess the diagnostic performance of 68Ga-PET/CT for the diagnosis of prosthetic valve infective endocarditis in comparison with the final diagnosis established according to the ESC 2023 criteria, after 3 months of follow-up, by a panel of experts. Patient suspected of infective endocarditis on prosthetic valves will be included. The index test (68Ga-PET/CT) and the usual test (18FDG-PET/CT) will be performed in all participants. The 68Ga-PET/CT will be performed the day before, the same day or the next day after 18FDG-PET/CT. . Both PET/CT scans will be interpreted independently by two experienced nuclear physicians, blinded to the final diagnosis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05446376
Study type Interventional
Source University Hospital, Bordeaux
Contact Carine GREIB, MD
Phone (0)5 57 65 64 83
Email carine.greib@chu-bordeaux.fr
Status Not yet recruiting
Phase Phase 2
Start date February 2024
Completion date February 2026
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05862025 - Evaluation of the Usefulness of Echocardiography in Patients With Staphylococcus Aureus Bacteremia (ET-AUREUS Study). N/A
Completed NCT03590106 - Cardiac Surgery Peer Recovery Support Program N/A
Not yet recruiting NCT05563662 - SURgical Registry of ENDocarditis EuRope
Completed NCT00947817 - Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism N/A
Recruiting NCT00624091 - Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL) Phase 4
Terminated NCT00695903 - Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia Phase 2
Recruiting NCT04992923 - Prospective Cohort Study of Patients With Infective Endocarditis at Pitié-Salpêtrière Hospital
Recruiting NCT03642379 - Cardiac Surgery Peer Support Recovery N/A
Recruiting NCT05264181 - Transcatheter Pulmonary Valve Implantation With SAPIEN 3 Valve
Recruiting NCT04257292 - NExt-Generation Sequencing and Cell Culture-based Characterization of S. Aureus in Infective Endocarditis
Active, not recruiting NCT03683355 - Characterization of RadiOlabeled Tracer Uptake Pattern in Noninfected Transcatheter Aortic Valves.
Not yet recruiting NCT00562653 - Autoantibodies and Clinical Symptoms in Infective Endocarditis Patients N/A
Not yet recruiting NCT00550823 - Cardiac Computarized Tomography in Infective Endocarditis N/A
Completed NCT03153384 - Impact of the Blood Culture Technique on the Diagnosis of Infective Endocarditis
Not yet recruiting NCT06194409 - The Incidence, Clinical Characteristics and Outcome of Infective Endocarditis Among Intravenous Drug Abusers Versus Non-Drug Abusers.
Completed NCT03945708 - Does Whole Blood Adsorber During CPB Reduce Vasoactive Drugs Postoperatively in Endocarditis Patients Undergoing Valve Surgery? N/A
Not yet recruiting NCT06269679 - CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis. N/A
Recruiting NCT03626571 - PET/MR Imaging In Patients With Infective Endocarditis
Completed NCT03612245 - Hygiene and Bucco-dental Status of Patients With Oral Streptococcal Endocarditis
Completed NCT02910856 - Infective Endocarditis in the Elderly