Characterization of RadiOlabeled Tracer Uptake Pattern in Noninfected

Status Active, not recruiting

Clinical Trial Summary

Therefore, the objective of the study is to characterize the pattern of radiolabeled tracer (18F-FDG) uptake in noninfected transcatheter heart valves in early follow-up after transcatheter aortic valve replacement (TAVR).

Clinical Trial Description

Diagnostic accuracy of Infective endocarditis (IE) is commonly challenging. Current clinical guidelines recommend the use of the modified Duke criteria, based on clinical, echocardiographic and biological findings, as well as the results of blood cultures and serologies. Advances in imaging techniques have resulted in an improvement in the identification of endocardial involvements and extracardiac complications of IE. Thus, recent works have demonstrated that 18F-FDG PET/CT and radiolabeled leucocyte SPECT/CT may improve the detection of silent endocardial lesions. The sites of radiotracer accumulation show regions of a high metabolic activity due to an inflammation or infection process. It is well known that, in surgical prosthetic valves, a mild radiotracer uptake in the perivalvular area may occur in the absence of infection and could therefore be considered as a normal pattern, particularly early after valve replacement. However, evidence of this phenomenon is lacking regarding transcatheter heart valves and the factors used to distinguish between normal and abnormal patterns of radiolabeled tracer are not standardized. The hypothesis is that patients undergoing transcatheter aortic valve replacement (TAVR) show a radiolabeled tracer (18F-FDG) uptake around the prosthesis despite the absence of IE. Moreover, the uptake pattern might vary between different platforms. Therefore, the objective of the study is to characterize the pattern of radiolabeled tracer uptake in noninfected transcatheter heart valves in early follow-up after TAVR. This will be a pilot study including 30 patients after TAVR procedure. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03683355
Study type	Observational
Source	Institut universitaire de cardiologie et de pneumologie de Québec, University Laval
Contact
Status	Active, not recruiting
Phase
Start date	November 9, 2018
Completion date	March 1, 2025

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05862025` - Evaluation of the Usefulness of Echocardiography in Patients With Staphylococcus Aureus Bacteremia (ET-AUREUS Study).	N/A
Completed	`NCT03590106` - Cardiac Surgery Peer Recovery Support Program	N/A
Not yet recruiting	`NCT05563662` - SURgical Registry of ENDocarditis EuRope
Completed	`NCT00947817` - Impact of Endothelial Cell Activation and Modifications of Haemostasis Induced by Infective Endocarditis on the Risk of Embolism	N/A
Recruiting	`NCT00624091` - Rationale, Design and Methods for the Early Surgery in Infective Endocarditis Study (ENDOVAL)	Phase 4
Terminated	`NCT00695903` - Phase 2 Study of Safety, Efficacy, and Pharmacokinetics of Higher Doses of Daptomycin and Vancomycin in MRSA Bacteremia	Phase 2
Recruiting	`NCT04992923` - Prospective Cohort Study of Patients With Infective Endocarditis at Pitié-Salpêtrière Hospital
Recruiting	`NCT03642379` - Cardiac Surgery Peer Support Recovery	N/A
Recruiting	`NCT05264181` - Transcatheter Pulmonary Valve Implantation With SAPIEN 3 Valve
Recruiting	`NCT04257292` - NExt-Generation Sequencing and Cell Culture-based Characterization of S. Aureus in Infective Endocarditis
Not yet recruiting	`NCT00562653` - Autoantibodies and Clinical Symptoms in Infective Endocarditis Patients	N/A
Not yet recruiting	`NCT00550823` - Cardiac Computarized Tomography in Infective Endocarditis	N/A
Completed	`NCT03153384` - Impact of the Blood Culture Technique on the Diagnosis of Infective Endocarditis
Not yet recruiting	`NCT06194409` - The Incidence, Clinical Characteristics and Outcome of Infective Endocarditis Among Intravenous Drug Abusers Versus Non-Drug Abusers.
Completed	`NCT03945708` - Does Whole Blood Adsorber During CPB Reduce Vasoactive Drugs Postoperatively in Endocarditis Patients Undergoing Valve Surgery?	N/A
Not yet recruiting	`NCT06269679` - CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis.	N/A
Recruiting	`NCT03626571` - PET/MR Imaging In Patients With Infective Endocarditis
Completed	`NCT03612245` - Hygiene and Bucco-dental Status of Patients With Oral Streptococcal Endocarditis
Completed	`NCT02910856` - Infective Endocarditis in the Elderly
Recruiting	`NCT02196753` - PET CT in Suspected CIED Infection, a Pilot Study - PET Guidance I	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Characterization of RadiOlabeled Tracer Uptake Pattern in Noninfected Transcatheter Aortic Valves. — COUNT

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms