Accelerated Treatment of Endocarditis — POETII  

Infectious Endocarditis Clinical Trial

Official title: Accelerated Treatment of Endocarditis

Status Recruiting

Clinical Trial Summary

Existing guidelines recommend a duration of antibiotic treatment of endocarditis of 4-6 weeks with one or two types of intravenously administered antibiotics. The long hospitalization increases several risks for the patient, including mental strain and increased loss of function. Furthermore, it poses a significant burden on health systems. Current guidelines fail to use available data collected from patients (echo, temperature, CRP, leukocytes, procalcitonin etc.) to determine duration of treatment. A strategy including these data in treatment algorithms ensures an individualized treatment, targeting the patient's course and response to treatment. Thus, the purpose of this open-label, prospective, non-inferiority, RCT study is to investigate the safety and effectiveness of shortening treatment of endocarditis based on the individual patient's initial treatment response, sampling 750 patients, approx. 200 patients with each type of bacteria (Streptococci; Enterococcus faecalis; Staphylococcus aureus). Interim analysis will be conducted when 150 patients have been included, to assess the frequency of the event rate and inclusion rate in order to adjust the intended size of the study population.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Endocarditis
• Infectious Endocarditis

• NCT number: NCT03851575
• Study type: Interventional
• Source: Rigshospitalet, Denmark
• Contact: Kasper K Iversen, MD
• Phone: +4528712753
• Email: kasper.k.iversen@gmail.com
• Status: Recruiting
• Phase: N/A
• Start date: January 17, 2019
• Completion date: December 10, 2023