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NCT05862688 Clinical Trial

A Cohort Study on Anti-microbial Stewardship in PICU

Infections Clinical Trial

Official title:
A Cohort Study on Anti-microbial Stewardship in PICU

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05862688
Other study ID # fdpicu-29
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date May 1, 2024
Est. completion date June 1, 2025

Study information
Verified date February 2024
Source Children's Hospital of Fudan University
Contact Jing Liu, Doctor
Phone 15800523953
Email liujinggg@126.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Appropriate antimicrobial therapy is essential to ensuring positive patient outcomes. Inappropriate or suboptimal utilization of antibiotics can lead to increased length of stay, multidrug-resistant infections, and mortality. Critically ill intensive care patients are at risk of antibiotic failure and secondary infections associated with incorrect antibiotic use. Initiating effective therapy for infections based upon patients' risk factors, collection of appropriate cultures, daily evaluation of clinical status, and laboratory data, including antibiotic time outs, and shortened duration of therapy are ways to improve patients outcomes. Antimicrobial stewardship teams can assist ICU providers in managing and implementing these tactics. ICUs would benefit from employing empiric guidelines for antibiotic use, collecting appropriate specimens and implementing molecular diagnostics, optimizing the dosing of antibiotics, and reducing the duration of total therapy.

Description:

Appropriate antimicrobial therapy is essential to ensuring positive patient outcomes. Inappropriate or suboptimal utilization of antibiotics can lead to increased length of stay, multidrug-resistant infections, and mortality. Critically ill intensive care patients are at risk of antibiotic failure and secondary infections associated with incorrect antibiotic use. Initiating effective therapy for infections based upon patients' risk factors, collection of appropriate cultures, daily evaluation of clinical status, and laboratory data, including antibiotic time outs, and shortened duration of therapy are ways to improve patients outcomes. Antimicrobial stewardship teams can assist ICU providers in managing and implementing these tactics. ICUs would benefit from employing empiric guidelines for antibiotic use, collecting appropriate specimens and implementing molecular diagnostics, optimizing the dosing of antibiotics, and reducing the duration of total therapy. This study conducted an antibiotic management cohort study in PICUs to discover the distribution of nosocomial infections in PICUs and to find controllable factors for the occurrence of nosocomial infections.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 1000
Est. completion date June 1, 2025
Est. primary completion date June 1, 2025
Accepts healthy volunteers No
Gender All
Age group 1 Month to 18 Years
Eligibility Inclusion Criteria: - Patients admitted to the ICU for more than 48 hour Exclusion Criteria: - Patients admitted to ICU less than 48 hours

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• antimicrobial therapy
antimicrobial therapy

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Children's Hospital of Fudan University

Outcome
Type Measure Description Time frame Safety issue
Primary survival rate the survival rate of children in 21 days after ICU admission 21 days after ICU admission
Secondary the length of ICU stay time the length of ICU stay time 21 days after ICU admission
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