Egyptian Arthroplasty Surgeons' Antibiotics Usage Awareness

Infections Joint Prosthetic Clinical Trial

Official title:

Attitudes of Prophylactic Antibiotic Utilization During Primary Total Hip and Knee Arthroplasty Among Egyptian Joint Replacement Surgeons

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06451224
• Other study ID #: 123456
• Status: Not yet recruiting
• Start date: June 15, 2024
• Est. completion date: July 30, 2024

Study information

• Verified date: June 2024
• Source: South Valley University
• Contact: Ahmed A. Khalifa, MD,FRCS
• Phone: 00201224466151
• Email: ahmed_adel0391[@]med.svu.edu.eg
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are procedures successfully applied to manage various end-stage chronic hip and knee diseases, such as osteoarthritis, rheumatoid arthritis, and femoral head avascular necrosis, as well as acute conditions, such as the neck of femur fractures, with excellent long-term functional outcomes. One of the devastating complications after such a procedure is periprosthetic joint infection (PJI). Various precautions are proposed to guard against such complications; one is the administration of perioperative antibiotics. However, injudicious or misuse of antibiotics could lead to the emergence of antimicrobial resistance, further complicating this matter. This is why various scientific and research organizations have proposed guidelines and a consensus for proper antibiotic use in perioperative THA and TKA surgery.

Antibiotic prophylaxis during primary THA and TKA can reduce the risk of PJI and surgical site infections. However, there is a lack of consensus on the optimal dosages and duration of prophylaxis, and guidelines vary among institutions. Alternatives such as extended oral antibiotic prophylaxis and different antibiotic regimens are being explored. International research is needed to establish best practices and determine the potential risks of antibiotic prophylaxis during primary THA and TKA. Unfortunately, the investigators are unaware of such guidelines proposed by any Egyptian health authority to guide and control the proper utilization of antibiotics during orthoapedic practice in general and joint replacement surgeries (THA and TKA) in particular.

Description:

This study will be an Online-based questionnaire investigating surgeons' perspectives on antibiotics utilization during primary total hip and knee arthroplasty surgeries and investigate their thoughts about the necessity for developing local guidelines.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 230
• Est. completion date: July 30, 2024
• Est. primary completion date: June 30, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 25 Years to 70 Years

Eligibility

Inclusion criteria:

All Egyptian registered members of the Egyptian Pelvis and Hip Society, practicing Egyptian joint replacement surgeons (performing surgeries as a leading surgeon) who are willing to participate

Exclusion criteria:

• Members not listed in the E-mail directory of the society

• Surgeons refusing to participate

• Young surgeons who are not practicing independently

Related Conditions & MeSH terms

• Infections Joint Prosthetic

Intervention

Other:
• Questionnaire
Online Questionnaire

Locations

Country	Name	City	State
Egypt	Assuit Faculty of Medicine	Assiut

Sponsors (2)

Lead Sponsor	Collaborator
South Valley University	Assiut University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	To determine the type of antibiotics administration during primary total hip and knee arthroplasty	The type of antibiotics will be determined as follows: the name of the antibiotic (brand or generic), and if single or dual antibiotics are used. These will be presented as numbers and percentages.	2 months
Secondary	To determine the dose of antibiotics administered during primary total hip and knee arthroplasty	The dose of antibiotics will be determined as grams or milligrams. Furthermore, the number of doses will be reported	2 months
Secondary	To determine the timing of antibiotics administration during primary total hip and knee arthroplasty	Regarding the timing, preoperative antibiotic administration will be reported in minutes	2 months
Secondary	To determine the length of antibiotics administration during primary total hip and knee arthroplasty	the length of antibiotic administration postoperatively will be calculated in days.	2 months