Infant, Very Low Birth Weight Clinical Trial
Official title:
Oropharyngeal Administration of Colostrum to Very Low Birth Weight Infants:Effects on Secretory Immunoglobulin A
The purpose of this study is to explore the effects of Oropharyngeal administration of colostrum to very low birth weight infants on sIgA and lactoferrin, in order to explore the protect immune function of colostrum to very low birth weight infants, to improve the utilization of breast milk and reduce infection rates of very low birth weight infants.
The number of very low born weight infants increased every year.they are suffer from many
questions.Recent studies have shown that Oropharyngeal administration of colostrum to very
low birth weight infants can reduce the time reach full enteral nutrition .But there are no
evidence support that it can promote infants' immune response. The hypothesis of the current
study is that Oropharyngeal administration of colostrum to very low birth weight infants may
increase the secretion of sIgA in urine and saliva.
The current study adopts randomized, double blind, controlled intervention trial, gives
Oropharyngeal administration of colostrums to very low birth weight infants in intervention
group and Oropharyngeal administration of Normal saline to control group. All indicators in
this study are discrete traits, for sIgA、Lactoferrin number in Saliva and urine, number of
CRP,time Begin oral feeding,time up to full enteral feeding, Person's chi-square tests were
used for comparisons. For Blood culture results,The number of necrotizing enterocolitis
(NEC) occurred, the investigators use Chi-square tests for comparisons between two groups.
The study expects that Oropharyngeal administration of colostrum to very low birth weight
infants can increase the secretion of sIgA in urine and saliva.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Supportive Care
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