Urine VEGF Levels in Very Low Birth Weight (VLBW) Infants

Status Recruiting

Clinical Trial Summary

VLBW infants are at risk of developing retinopathy of prematurity (ROP). In the first phase of ROP there is a down-regulation of retinal VEGF-expression because of postnatal relative hyperoxia, followed by an upregulation of VEGF mediated through retinal hypoxia, which leads to pathologic vessel formation. VEGF acts through binding to the specific receptor FLT-1, the soluble form sFLT-1 is a specific antagonist of VEGF action. Erythropoietin, given to VLBW infants to prevent anemia, may stimulate VEGF-production in neuronal cells. Currently, there are no data published about VEGF urine-levels in VLBW infants and it is not known, if urine VEGF-levels may serve as a non-invasive marker of ROP-risk. Further shall be investigated, if erythropoietin-therapy increases urine VEGF-levels and if there is a correlation with ROP-development.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00799721
Study type	Observational
Source	Charite University, Berlin, Germany
Contact	Anke Reinhold, Doctor
Phone	+49/177/2950661
Email	anke.reinhold@charite.de
Status	Recruiting
Phase	N/A
Start date	August 2008
Completion date	December 2010

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02913677` - Prolonged Minimal Enteral Nutrition Versus Slowly Advancing Enteral Nutrition in Very Low Birth Weight Infants:	N/A
Completed	`NCT02379728` - Ghana PrenaBelt Trial: A Positional Therapy Device to Reduce Still-Birth	N/A
Completed	`NCT01341236` - Near Infrared Spectroscopy (NIRS) and Superior Mesenteric Artery (SMA) Doppler Patterns as Predictor of Feeding Tolerance in Very Low Birth Weight (VLBW) IntraUterine Growth Restricted (IUGR) and NON IUGR Infants	Phase 4
Completed	`NCT05217186` - Associations Between Early Neonatal Neuroimaging, Hammersmith Infant Neurological Examination and General Movements
Completed	`NCT03082313` - Movement-based Infant Intervention	N/A
Terminated	`NCT01430832` - Developmental Outcomes of Extreme Prematurity, 5-15 Years Postpartum
Terminated	`NCT02599545` - Testosterone and Cortisol Levels in Infants
Completed	`NCT02583776` - Continuous Glucose Monitoring and Preterm Infants	Phase 4
Active, not recruiting	`NCT01809548` - Preterm Infants on Early Solid Foods	N/A
Completed	`NCT01363167` - Identifying Vitamin D Deficiency in Very Low Birth Weight Infant (VLBW) Infants Part 2	N/A
Completed	`NCT01193270` - Vitamin E for Extremely Preterm Infants	Phase 1
Completed	`NCT02078687` - Growth, Risks of Allergy and Metabolic Syndrome in 6 Year Old Children Born Preterm Compared to Postdischarge Nutrition	N/A
Completed	`NCT00760942` - Liquid Preterm Formula Versus Powdered Human Milk Fortifier in VLBW Infants	N/A
Completed	`NCT02280031` - Effect of Low Dose Aspirin on Birthweight in Twins: The GAP Trial.	Phase 2
Completed	`NCT01717625` - The Efficacy and Safety of Montelukast Sodium in the Prevention of Bronchopulmonary Dysplasia	Phase 2
Completed	`NCT00601081` - Human Milk Fortifier and Cytokine Profile	N/A
Completed	`NCT00009646` - Trial of Indomethacin Prophylaxis in Preterm Infants (TIPP)	Phase 3
Completed	`NCT00579943` - Regulation of Cerebral Blood Flow in Very Low Birth Weight Infants	N/A
Completed	`NCT02389478` - Oropharyngeal Administration of Colostrum to Very Low Birth Weight Infants	N/A
Recruiting	`NCT02016638` - Sleep Quality in Pregnancy and Its Impact on Pregnancy Outcomes	N/A