Infant,Premature Clinical Trial
Official title:
Prematurity-Related Ventilatory Control (PRE-VENT): Role in Respiratory Outcomes Clinical Research Centers (CRC) - Specific Aim 3
To determine if servo-controlled oxygen environment is associated with reduction in (a) bradycardia events, (b) hypoxemic time, (c) bradycardia time, (d) apneic episodes
This study will enroll the subset of infants enrolled in the main study (PreVENT Aim 1; 401-1000g at birth and/or 22w 0d-28w 6d; enrolled at <1 week postnatal age; eligible for full care and surviving beyond 24 hours, with informed consent; and with no major malformations) who are receiving oxygen supplementation at 32w and 36w postmenstrual age (PMA), and are not judged too unstable by the Attending neonatologist. For infants on oxygen supplementation at 32w PMA, the investigators will use data from the 96 hours of intensive multiparametric physiologic monitoring at 32w PMA. For infants on oxygen supplementation at 36w PMA, we will use the 96 hours of intensive multiparametric physiologic monitoring at 36w PMA as well as data from the sleep study. The first 24 hours of data collection will be the baseline data. Over the next 72 hours, the investigators will evaluate 3 interventions in a cross-over manner with the initial intervention (cannula or oxygen environment) randomly assigned: Intervention 1 (24-48h of data), Intervention 2 (48-72h of data) and Intervention 3 (72-96h of data). ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03445689 -
Oxygenation Instability and Maturation of Control of Breathing in Premature Infants
|
||
| Completed |
NCT03245723 -
Cardiac Function and Metabolism in Young Adults Born Premature (PET-MRI)
|
N/A | |
| Active, not recruiting |
NCT03575897 -
Serial Assessment of Body Fat Accrual in Very Preterm Infants
|
N/A | |
| Completed |
NCT03082313 -
Movement-based Infant Intervention
|
N/A | |
| Completed |
NCT03696758 -
Improving Right Ventricular Function in Young Adults Born Preterm
|
Phase 2 | |
| Withdrawn |
NCT01569633 -
Use of Prokinetics in Early Enteral Feeding in Preterm Infants
|
N/A | |
| Terminated |
NCT03532555 -
Enteral Zinc to Improve Growth in Infants at Risk for Bronchopulmonary Dysplasia
|
N/A | |
| Completed |
NCT03230032 -
Pacifier Activated Device and Mother's Voice in Infants at High-risk for Cerebral Palsy
|
N/A | |
| Recruiting |
NCT03693287 -
Personalized vs Standardized PN for Preterm Infants >1250g
|
Phase 4 | |
| Terminated |
NCT03542812 -
L-citrulline and Pulmonary Hypertension Associated With Bronchopulmonary Dysplasia
|
Early Phase 1 | |
| Completed |
NCT03434743 -
Non-nutritive Sucking and Breastfeeding in Preterm Infants
|
N/A | |
| Active, not recruiting |
NCT03168516 -
Effects of Closed-loop Automatic Control of FiO2 in Extremely Preterm Infants
|
Phase 3 | |
| Completed |
NCT03357458 -
Parent-child Interactions, Child Developmental Health, and Health System Costs at 6 Months Corrected Age
|
N/A | |
| Recruiting |
NCT03521063 -
Efficacy of Adding Budesonide to Poractant Alfa to Prevent Bronchopulmonary Dysplasia.
|
Phase 4 | |
| Recruiting |
NCT03501485 -
Impact of Protein Supplementation to Mother Milk on Resting Energy Expenditure (REE) in Growing Healthy Preterm Infants.
|
||
| Recruiting |
NCT06416956 -
Baby-CINO: CaffeINe Treatment Optimisation in Premature Infants
|
||
| Completed |
NCT03280381 -
Nifty Feeding Cup Versus Generic Medicine Cup Preterm Infants Who Have Difficulty Breastfeeding
|
N/A | |
| Completed |
NCT03586856 -
Comparison of Leakage With Nasal Prongs and Nasal Mask Interface in Newborns Receiving CPAP Treatment
|
N/A | |
| Completed |
NCT03333161 -
Prematurity Related Ventilatory Control (PRE-VENT) - Specific Aim 2
|
N/A | |
| Active, not recruiting |
NCT03558737 -
Nasal High-frequency Jet Ventilation (nHFJV) Following Extubation in Preterm Infants
|
N/A |