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Prematurity Related Ventilatory Control (PRE-VENT) - Specific Aim 2

Infant,Premature Clinical Trial

Official title:
Prematurity-Related Ventilatory Control (PRE-VENT): Role in Respiratory Outcomes Clinical Research Centers (CRC)

Clinical Trial Summary

To determine if late (at or beyond postnatal day 14) mild permissive hypercapnia is associated with reduction in apnea, bradycardia, and hypoxemic episodes and with improved stability of oxygenation.

Clinical Trial Description

Preterm infants who remain intubated or on nasal mechanical ventilation (IMV) at 14 days postnatal age, meet blood gas criteria, have transcutaneous carbondioxide (TcCO2) monitoring with TcCO2 values that trend and correlate appropriately with PaCO2, and are not judged too unstable by Attending neonatologist will qualify. The investigators will use the data from the 96 hours of intensive multiparametric physiologic monitoring at 2 weeks postnatal age. The first 24 hours of data collection will be the baseline data. Over the next 72 hours, the investigators will evaluate 3 interventions in a cross-over manner with the initial intervention randomly assigned: Intervention 1 (24-48h of data), Intervention 2 (48-72h of data) and Intervention 3 (72-96h of data). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03333161
Study type Interventional
Source University of Alabama at Birmingham
Contact
Status Completed
Phase N/A
Start date April 9, 2018
Completion date March 30, 2021
View Details
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