Influence of Intestinal Microbiota Implantation in Preterm Infants on Microbiota and Immune Orientation at 3 Years — PrimiBiota  

Infant, Premature Clinical Trial

Official title: Influence of Intestinal Microbiota Implantation Parameters in the Neonatal Period in Premature Infants on Microbiota Profiles and Immune Orientation at 3 Years of Age

Status Active, not recruiting

Clinical Trial Summary

The main objective of this research is to study the links between changes in the intestinal microbiota (in terms of diversity) during the first 6 weeks of life for preterm infants and the presence / absence of a TH1 immune status at 36 months of age.

Clinical Trial Description

The secondary objectives are to study the links between changes of the intestinal microbiota premature infants in terms of:

• changing diversity of the microbiota in the first 6 weeks of life;

• changes in the bacterial community (UniFrac study) during the first 6 weeks of life;

• diversity of the microbiota up to 6 weeks;

-AND-

• diversity of the microbiota at 1, 2 & 3 years;

• bacterial communities (UniFrac study) at 1, 2 & 3 years;

• lymphocyte subpopulation profiles at 3 years;

• serum immunoglobulin A, G, M, E levels at 3 years;

• history of infectious episodes, allergic and inflammatory episodes during the first 3 years of life.

The links between certain variables known in the literature and neonatal microbiota will be confirmed / studied in our population:

• mode of delivery;

• length (and type) of antibiotic therapy in the neonatal period;

• duration of breastfeeding. ;

Related Conditions & MeSH terms

• Infant, Premature
• Premature Birth

• NCT number: NCT02738411
• Study type: Observational
• Source: Centre Hospitalier Universitaire de Nimes
• Status: Active, not recruiting
• Start date: May 12, 2017
• Completion date: June 30, 2024