Comparison of Etomidate, Propofol and Etomidate-propofol Combination in Terms of Effects on Haemodynamic Response to Intubation

Induction of Anaesthesia Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02186990
• Other study ID #: Odu-2
• Status: Completed
• Phase: Phase 4
• First received: June 6, 2014
• Last updated: August 12, 2014
• Start date: May 2014

Study information

• Verified date: August 2014
• Source: T.C. ORDU ÜNIVERSITESI
• Contact: n/a
• Is FDA regulated: No
• Health authority: Turkey: Drug and Medical Device Institution
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the effect of propofol, etomidate and propofol-etomidate combination on hemodynamic responses during laryngoscopy and tracheal intubation and assess the adverse effect related to this drugs.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 90
• Est. primary completion date: August 2014
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• between 18 - 65 age

• ASA I - II status

• elective surgery

Exclusion Criteria:

• emergency surgery

• pregnancy

• alcohol and drug abuse

• HT and cardiovascular disease

• BMI > 25 kg/m2

• hypersensitivity against study drug

• sedative drug use in last month

• difficult intubation

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Induction of Anaesthesia

Intervention

Drug:
• propofol
2,5 mg/kg
• etomidate
0,3 mg/kg
• etomidate-propofol
0,15 mg/kg etomidate + 1,25 mg/kg propofol

Locations

Country	Name	City	State
Turkey	Anesthesiology and Reanimation Dept. Ordu University Training and Research Hospital	Altinordu	Ordu

Sponsors (1)

Lead Sponsor	Collaborator
T.C. ORDU ÜNIVERSITESI

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	haemodynamic values	e.g., heart rate, blood pressure (mean arterial pressure)	in ten minutes after intubation	No
Secondary	adverse effect of study drugs	e.g. myoclonus, injection pain, allergy, skin rash	within in 30 minutes drug administration	No