Study of Decitabine Combined With HAAG Regimen in Newly Diagnosed ETP-ALL/LBL, T/M-MPAL and ALL/LBL With Myeloid or Stem Cell Markers Patients

Induction Chemotherapy Clinical Trial

Official title:
A Phase 3, Open Label, Single Arm, Multi-Center Study to Evaluate the Efficacy and Safety of Decitabine Combined With HAAG Regimen in Newly Diagnosed ETP-ALL/LBL, T/M-MPAL and ALL/LBL With Myeloid or Stem Cell Markers Patients

Status Recruiting

Clinical Trial Summary

The purpose of this study is to evaluate the efficacy and safety of decitabine combined with HAAG regimen in the treatment of newly diagnosed patients with ETP-ALL/LBL, T/M-MPAL and ALL/LBL with myeloid or stem cell markers.

Clinical Trial Description

This is a phase 3, open label, single arm, multi-center study in newly diagnosed ETP-ALL/LBL, T/M-MPAL and ALL/LBL patients who have myeloid or stem cell markers. The patients will receive decitabine combined with HAAG regimen in the induction treatment. The patients who respond to induction chemotherapy will undergo consolidation chemotherapy, and an optional allogeneic hematopoietic stem cell transplantation and post-transplantation maintenance treatment with decitabine according to patient's wishes. ;

Study Design

Related Conditions & MeSH terms

Acute T-Lymphocytic Leukemia
Induction Chemotherapy
Leukemia
Leukemia, T-Cell
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
T-cell Lymphoblastic Lymphoma Leukemia
T-cell/Myeloid Mixed Phenotype Acute Leukemia

Clinical Trial Details

NCT number	NCT04446130
Study type	Interventional
Source	The First Affiliated Hospital of Soochow University
Contact	Xiaowen Tang, Ph.D.
Phone	(0086)51267781856
Email	xwtang1020@163.com
Status	Recruiting
Phase	Phase 3
Start date	January 1, 2019
Completion date	January 1, 2024

View Details

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