Induced Pluripotent Stem Cells Clinical Trial
Official title:
Developing Derived Induced Pluripotent Stem Cells From Blood as a Model for the Study to Understand Imprinted Disorders
Fetal and postnatal growth is finely regulated by genetic, epigenetic and environmental mechanisms. Parental imprinting is a regulatory mechanism that allows monoallelic expression of certain genes from a single parental allele through differential DNA methylation. Imprinted genes play a very important role in the control of fetal and postnatal growth. The pathophysiological mechanisms of these epimutations are largely unknown. Studying the consequences of these epimutations on the molecular signature of the imprinted gene network in these patients would provide a better understanding of the epigenetic mechanisms regulating fetal growth. As these genes are weakly expressed in fibroblasts, these studies will be carried out on pluripotent stem cells or IPSCs (Induced Pluripotent Stem Cells).
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01534624 -
Stem Cell Study of Genetics and Drug Addiction
|
||
| Withdrawn |
NCT02056613 -
Blood Collection From Healthy Volunteers and Patients for the Production of Clinical Grade Induced Pluripotent Stem Cell (iPSC) Products
|
||
| Recruiting |
NCT01454765 -
Generation of Haploid Stem Cells From Human Germ Cells
|
N/A |