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Incisional Hernia clinical trials

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NCT ID: NCT01280370 Completed - Clinical trials for Incisional Hernia Repair

Prospective Evaluation of Laparoscopic and Open Incisional Hernia Repair: a Multicenter Cohort Study

IHR_SALTC
Start date: September 2010
Phase:
Study type: Observational

Nowadays incisional hernia are primarily repaired using prosthetic meshes. In Switzerland such meshes are mainly implanted via open or laparoscopic approach. The differential impact of these two types of surgical technique on recurrence rate will be investigated with this study. With this multicenter cohort study the outcomes of laparoscopic and open incisional hernia repair will be investigated prospectively. Hernia recurrence is the main outcome measure. Hypothesis: Laparoscopic incisional hernia repair is associated with a lower recurrence rate compared to open incisional hernia repair.

NCT ID: NCT01247389 Completed - Clinical trials for Laparoscopic Colectomy

Incisional Hernia After Midline Versus Transverse Extraction Incision in Laparoscopic Colectomy

Start date: July 2011
Phase: N/A
Study type: Interventional

Incisional hernia (IH) is a common complication of midline laparotomy. Despite the hope that laparoscopic colon resection would result in fewer incisional hernias, prospective studies demonstrate a similar incidence to open surgery. Observational studies suggest that the rate of incisional hernia after laparoscopic colon resection may be reduced with the use of a transverse compared to a midline extraction incision. However, no randomized trails are available, and a midline extraction incision for hemicolectomy remains the standard current approach. The investigators hypothesize that the use of a lower abdominal transverse muscle splitting incision for specimen extraction in laparoscopic colon surgery will result in fewer incisional hernias compared to a midline periumbilical extraction incision.

NCT ID: NCT01203553 Completed - Incisional Hernias Clinical Trials

Prophylactic Mesh Implantation for the Prevention of Incisional Hernia

ProphMesh
Start date: January 2011
Phase: N/A
Study type: Observational

Incisional hernias are primarily repaired using prosthetic meshes. In Switzerland such meshes are mainly implanted via open or laparoscopic approach. The differential impact of these two types of surgical technique on recurrence rate will be investigated with this study. With this multicenter cohort study the outcomes of laparoscopic and open incisional hernia repair will be investigated prospectively. Hernia recurrence is the main outcome measure.

NCT ID: NCT01162564 Completed - Ventral Hernia Clinical Trials

Flexible Composite Next Generation Tissue Separating Mesh in Laparoscopic Incisional/Ventral Hernia Repair

Start date: June 2010
Phase: N/A
Study type: Observational

This is a multi-center, observational study of incisional/ventral hernia repair with NG-TSM laparoscopically. The study is not randomized and has a single treatment design assessing NG-TSM intra-operatively, its ease of use and handling characteristics.

NCT ID: NCT00998907 Completed - Wound Infection Clinical Trials

PDS*Plus and Wound Infections After Laparotomy

PDS*plus
Start date: September 2009
Phase: N/A
Study type: Interventional

The aim of this study is to ascertain if the use of PDS plus® reduces the number of wound infections and incisional hernia after midline and transverse laparotomy comparing to polyglactin suture.

NCT ID: NCT00907842 Completed - Incisional Hernia Clinical Trials

Hernia Prevention in Stomas

Start date: April 2010
Phase: N/A
Study type: Interventional

Knowing that the risk of stoma associated herniation (parastomal or incisional) is 30-50% and the associated morbidity significant, standard placement of a prophylactic mesh upon stoma creation might prevent parastomal (or incisional herniation, after closure) and improve the quality of life of a large group of patients. This study is meant to be a pilot study to see whether the mesh related risks of infection and adhesion morbidity are acceptable if the mesh is placed intraperitoneally.

NCT ID: NCT00891254 Completed - Incisional Hernia Clinical Trials

Long-term Follow-up of Incisional Hernia Repaired With Intraperitoneal Mesh

Start date: January 2009
Phase: Phase 1
Study type: Interventional

The intraperitoneal repair has been proven safe for the repair of incisional hernia and is accepted, together with the subfascial or retromuscular repair as the "gold-standard" for the repair of incisional hernia. However no studies have convincingly proven that this approach is better than the on-lay repair. The authors believe that the intraperitoneal repair performs better than the on-lay repair for incisional hernia.

NCT ID: NCT00775034 Completed - Incisional Hernia Clinical Trials

Drainage Versus Sealant in Double Blinded Monocentric Open Incisional Hernia Repair

DREAM
Start date: January 27, 2010
Phase: Phase 4
Study type: Interventional

Mesh repair for open incisional hernia repair with fibrin sealant or with drainage

NCT ID: NCT00761475 Completed - Clinical trials for Incisional Hernia Occurence

Primary Mesh Closure of Abdominal Midline Wounds

PRIMA
Start date: February 2009
Phase: Phase 3
Study type: Interventional

Incisional hernia is the most frequently seen long term complication in surgery causing much morbidity and even mortality in patients. Despite studies on the optimal closing technique for laparotomies, the risk for incisional hernia after midline incision remains about 5-20 %. Major risk factors for incisional hernia after a laparotomy, like obesity, steroid use, malnutrition, smoking and connective tissue disorders, are known. Despite this knowledge, there has not yet been developed a sufficient method for prevention. One specific group of high risk patients are patients with an abdominal aortic aneurysm (AAA). The relationship between aortic aneurysm and other abdominal wall hernias, like inguinal hernias, has been reported. Retrospective and prospective studies have shown an average risk for incisional hernia after AAA repair of 31.6 %. Another high risk group is the group of obese patients. Patients with a BMI of more than 27 have a high risk of developing an incisional hernia after midline incision with an incidence of 22% after 12 months. Considering only 50 % of incisional hernia will be clinically evident in the first 12 months, the total incidence will be above 30%. This high risk group of patients with obesitas and aneurysmatic disease can benefit most from prevention. Some small studies have been performed to evaluate the usefulness and safety of primary laparotomy wound closure with the aid of prosthetic mesh. These studies show a very low risk for incisional hernias and a low infection rate, even when used in contaminated wounds such as colostomal surgery. However, there has not been performed an adequate randomized controlled trial to study the prevention of incisional hernias. Our hypothesis is that incisional hernia prevention with use of prosthetic mesh after laparotomy is effective in patients with aortic aneurysm and in obese patients with a BMI of more than 27.

NCT ID: NCT00647569 Completed - Incisional Hernia Clinical Trials

Trial of Collagen Mesh for Prevention of Ventral Hernia After Surgery for Advanced Pelvic Cancer

VRAM
Start date: April 2008
Phase: Phase 3
Study type: Interventional

The aim of the present project is to investigate whether use of biological mesh at the donor site of the rotation flap in closure of the abdominal wall reduce the frequency of incisional hernia formation compared to the usual abdominal wall closure after abdominal rotation flap operation in surgery for advanced pelvic cancer.