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NCT06251440 Clinical Trial

Initial Experience of Transabdominal Fetal Reduction in Nepal

In Vitro Fertilization Clinical Trial

Official title:
Transabdominal Fetal Reduction in Higher Order Multiple Pregnancies - a Pioneer Study in Nepal

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT06251440
Other study ID # 20/2020
Secondary ID
Status Completed
Phase
First received
Last updated
Start date February 1, 2018
Est. completion date April 30, 2023

Study information
Verified date February 2024
Source Grande International Hospital, Nepal
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Multifetal pregnancies are common in in vitro fertilization. Multifetal gestation increases maternal and fetal morbidity and mortality. We perform fetal reduction in our hospital by intra-thoracic injection of potassium chloride. This manuscript is description of our initial experience.

Description:

Assisted reproductive technology and stimulated conception have led to an increase in the prevalence of high order multifetal pregnancies (MFPs) in recent times. MFPs are associated with high maternal and fetal complications. Fetal mortality and morbidity are due to complications of prematurity. Prevalence of pregnancy induced hypertension, pre-eclampsia, eclampsia, antepartum hemorrhage, post-partum hemorrhage, gestational diabetes and difficult deliveries are more in mother with MFP. Embryo/Fetal reduction in high order MFPs helps in prolongation of gestation. Multifetal pregnancy reduction (MFPR) is secondary prevention of the risks associated with MFP. Trans-abdominal intracardiac injection of KCl is a simple, safe and effective technique for MFPR. We are among the first few centers in Nepal doing MFPR. In this study, we are sharing our initial experience of the procedure.

Recruitment information / eligibility
Status Completed
Enrollment 108
Est. completion date April 30, 2023
Est. primary completion date April 30, 2023
Accepts healthy volunteers No
Gender Female
Age group 18 Years to 45 Years
Eligibility Inclusion Criteria: - pregnant females with multifetal gestation who opt to undergo fetal reduction Exclusion Criteria: - who do not give consent

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Fetal Reduction
Under ultrasound guidance, intracardiac injection of 0.2 to 3.0 ml of 15% weight/volume (2 miliequivalent/mililiter ) potassium chloride (KCl) was administered via transabdominal route

Locations
Country Name City State
Nepal Prajwal Dahal Kathmandu Bagmati

Sponsors (1)
Lead Sponsor Collaborator
Grande International Hospital, Nepal

Country where clinical trial is conducted

Nepal, 

Outcome
Type Measure Description Time frame Safety issue
Primary Transabdominal ultrasonography guided fetal reduction is safe and effective in first trimester To share initial experience of transabdominal multifetal pregnancy reduction (MFPR) in Nepal 4.5 years
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