In-vitro Fertilization Clinical Trial
Official title:
Combination of Gonadotropin-releasing Hormone Agonist and Human Chorionic Gonadotropin Triggered by Normal Responder in GnRH-antagonist Cycles
Background
The trigger for the final maturation of the ovum by providing integration of Human Chorionic
Gonadotropin (hCG) and Gonadotropin - releasing hormone (GnRH) agonist was first introduced
long ago, but clinically not accepted until the advent of GnRH antagonist protocol in IVF
treatment.
In a recently published work which compared two types of ovulation induction (standard dose
of hcg and in combination of GnRH agonist) in women with normal ovarian response, there was
a statistically significant increase in the rates of implantation, clinical pregnancies and
live births rates by providing integration of hCG and GnRH agonist.
To conclude, providing GnRH agonist in combination of hCF in standard dose is today an
accepted treatment for final maturation of the ovums.
OBJECTIVE
The investigators objective is to investigate whether providing integrated treatment of
Gonadotropin - releasing hormone (GnRH) Agonist and human Chorionic Gonadotropin (hCG) to
final maturation of the ovum can improve the quality of the embryos, clinical pregnancies
and live births rates in women treated with GnRH Antagonist protocol.
The main objective is to compare between two existing treatments.
Background
The trigger for the final maturation of the ovum by providing integration of Human Chorionic
Gonadotropin (hCG) and Gonadotropin - releasing hormone (GnRH) agonist was first introduced
long ago, but clinically not accepted until the advent of GnRH antagonist protocol in IVF
treatment.
In order to prevent Ovarian Hyperstimulation Syndrome in the treatment cycles with GnRH
antagonist protocol, it is possible to make the final maturation of the ovums by providing
GnRH agonist.
In a recently published work which compared two types of ovulation induction (standard dose
of hcg and in combination of GnRH agonist) in women with normal ovarian response, there was
a statistically significant increase in the rates of implantation, clinical pregnancies and
live births rates by providing integration of hCG and GnRH agonist.
To conclude, providing GnRH agonist in combination of hCF in standard dose is today an
accepted treatment for final maturation of the ovums.
OBJECTIVE
The investigators objective is to investigate whether providing integrated treatment of
Gonadotropin - releasing hormone (GnRH) Agonist and human Chorionic Gonadotropin (hCG) to
final maturation of the ovum can improve the quality of the embryos, clinical pregnancies
and live births rates in women treated with GnRH Antagonist protocol.
The main objective is to compare between two existing treatments.
PATIENTS & METHODS
Women treated through IVF by protocol Gnarl - Antagonist
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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